SMG7 antibody (Internal Region)

Catalog No. ABIN7384295

Product Details anti-SMG7 Antibody

Target: SMG7 (Smg-7 Homolog, Nonsense Mediated mRNA Decay Factor (SMG7))

Binding Specificity: Internal Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMG7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Affinity purification

Immunogen: Synthesized peptide derived from the Internal region of human SMG7

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SMG7

Target: SMG7 (Smg-7 Homolog, Nonsense Mediated mRNA Decay Factor (SMG7))

Alternative Name: SMG7 (SMG7 Products)

Synonyms: 9430023P16Rik antibody, mKIAA0250 antibody, C1orf16 antibody, EST1C antibody, SGA56M antibody, Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) antibody, SMG7, nonsense mediated mRNA decay factor antibody, Smg7 antibody, SMG7 antibody

Background: Breast cancer-associated antigen SGA-56M,C1orf16,EST1 like protein C,EST1 telomerase component homolog C,EST1-like protein C,EST1C,ever shorter telomeres 1C,FLJ23717,hSMG-7,nonsense mediated mRNA decay factor (C. elegans),Protein SMG7,SGA56M,SMG 7,SMG-7 homolog,Smg7,SMG7,This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD), a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.SMG7 (SMG7, Nonsense Mediated MRNA Decay Factor) is a Protein Coding gene. Among its related pathways are Gene Expression and Viral mRNA Translation. GO annotations related to this gene include protein phosphatase 2A binding. An important paralog of this gene is SMG6.

Molecular Weight:

Observed_MW: 127kDa

Calculated_MW: 127kDa

Gene ID: 9887

UniProt: Q92540