FOXO3 antibody (C-Term)

Catalog No. ABIN7448571

This anti-FOXO3 antibody is a Rabbit Polyclonal antibody detecting FOXO3 in IHC. Suitable for Human and Mouse.

Quick Overview for FOXO3 antibody (C-Term) (ABIN7448571)

Target: FOXO3 (Forkhead Box O3 (FOXO3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXO3 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-FOXO3 Antibody

Binding Specificity: C-Term

Purpose: Rabbit anti-FOXO3a IHC Antibody, Affinity Purified

Predicted Reactivity: Rat,Chicken,Turkey,Sheep,Bovine,Dog,Horse,Rabbit,Guinea pig_10141,Pig,Panda,Orangutan,Monkey,Gorilla,Chimpanzee,White-tufted-ear marmoset,Tasmanian devil,African elephant,Gray short-tailed opossum,Green anole,Little brown bat,Naked mole rat,Chinese hamster,Domestic water buffalo,Small-eared galago,Crab-eating macaque,Northern white-cheeked gibbon,Thirteen-lined ground squirrel,Zebra finch

Purification: Affinity Purified

Immunogen: Between AA 625 and C-term

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for FOXO3

Target: FOXO3 (Forkhead Box O3 (FOXO3))

Alternative Name: FOXO3a

Background: Background: Forkhead box protein 03A (FOXO3a) belongs to a large family of Forkhead proteins that possesses a winged-helix DNA-binding domain called Forkhead box (FOX). FOXO3a is a transcription factor that functions to induce apoptosis in the absence of survival factors and in response to oxidative stress. Under conditions of oxidative stress FOXO3a is acetylated and localized to the nucleus where it may act as a transcriptional repressor.

Gene ID: 2309

NCBI Accession: NP_963853

UniProt: O43524

Pathways: Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis