PCSK9 antibody (AA 450-500)

Catalog No. ABIN7451107

This Rabbit Polyclonal antibody specifically detects PCSK9 in IP. It exhibits reactivity toward Human.

Quick Overview for PCSK9 antibody (AA 450-500) (ABIN7451107)

Target: PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCSK9 antibody is un-conjugated

Application: Immunoprecipitation (IP)

Product Details anti-PCSK9 Antibody

Binding Specificity: AA 450-500

Purpose: Rabbit anti-PCSK9 Antibody, Affinity Purified

Predicted Reactivity: Monkey,Gorilla,Chimpanzee

Purification: Affinity Purified

Immunogen: Between AA 450 and 500

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: Not recommended. ABIN7451107 has not performed satisfactorily when used for WB of PCSK9 in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of PCSK9.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for PCSK9

Target: PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))

Alternative Name: PCSK9

Background: Background: The gene PCSK9, also known as NARC1, encodes for proprotein convertase subtilisin/kexin type 9. A member of the subtilisin-like proprotein convertase family, this protein is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia [taken from NCBI Entrez Gene (Gene ID: 255738)].

Gene ID: 255738

UniProt: Q8NBP7