IGKV1-27 antibody (AA 525-575)

Catalog No. ABIN7451604

Product Details anti-IGKV1-27 Antibody

Target: IGKV1-27 (Immunoglobulin kappa Variable 1-27 (IGKV1-27))

Binding Specificity: AA 525-575

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IGKV1-27 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Purpose: Rabbit anti-A20 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 525 and 575

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for IGKV1-27

Target: IGKV1-27 (Immunoglobulin kappa Variable 1-27 (IGKV1-27))

Alternative Name: A20 (IGKV1-27 Products)

Synonyms: A20 antibody, OTUD7C antibody, TNFA1P2 antibody, TNF alpha induced protein 3 antibody, TNFAIP3 antibody

Background: Background: Zinc-finger protein A20 was identified as a transcript that was rapidly induced by tumor-necrosis factor alpha (TNF-alpha). A20 is an essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Upon TNF stimulation, A20 deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains [taken from the Universal Protein Resource (UniProt) P21580].

Gene ID: 7128

NCBI Accession: NP_006281

UniProt: P21580

Pathways: Activation of Innate immune Response