IGKV1-27 antibody (AA 241-356)

Catalog No. ABIN7872742

The Mouse Monoclonal anti-IGKV1-27 antibody (Clone TNFAIP3-2813) (ABIN7872742) specifically detects IGKV1-27 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for IGKV1-27 antibody (AA 241-356) (ABIN7872742)

Target: IGKV1-27 (Immunoglobulin kappa Variable 1-27 (IGKV1-27))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IGKV1-27 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TNFAIP3-2813

Product Details anti-IGKV1-27 Antibody

Binding Specificity: AA 241-356

Purpose: A20 Antibody / TNFAIP3

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 241-356 from the human protein was used as the immunogen for the A20 antibody.

Isotype: IgG2c, kappa

Application Details

Application Notes: Optimal dilution of the A20 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the A20 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for IGKV1-27

Target: IGKV1-27 (Immunoglobulin kappa Variable 1-27 (IGKV1-27))

Alternative Name: A20

Background: A20 (also known as TNFAIP3) is a zinc finger protein and inhibits NF-kappa B activation as well as TNF-mediated apoptosis. The protein has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. A20 is as a tumor suppressor and has been shown to protect MCF-7 breast carcinoma cells from TNF-induced apoptosis. High A20 expression levels were observed in more aggressive breast tumors (ER-negative, progesterone receptor-negative and high histological grade). These findings strongly suggest that A20 is a key protein involved in tamoxifen resistance.

UniProt: P21580

Pathways: Activation of Innate immune Response