IGKV1-27 antibody (AA 241-356)

Catalog No. ABIN7872741

The Mouse Monoclonal anti-IGKV1-27 antibody is suitable to detect IGKV1-27 in samples from Human. It has been validated for IHC (p).

Quick Overview for IGKV1-27 antibody (AA 241-356) (ABIN7872741)

Target: IGKV1-27 (Immunoglobulin kappa Variable 1-27 (IGKV1-27))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IGKV1-27 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: TNFAIP3-2813

Product Details anti-IGKV1-27 Antibody

Binding Specificity: AA 241-356

Purpose: A20 Antibody / TNFAIP3 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 241-356 from the human protein was used as the immunogen for the A20 antibody.

Isotype: IgG2c, kappa

Application Details

Application Notes: Optimal dilution of the A20 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the A20 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for IGKV1-27

Target: IGKV1-27 (Immunoglobulin kappa Variable 1-27 (IGKV1-27))

Alternative Name: A20

Background: A20 (also known as TNFAIP3) is a zinc finger protein and inhibits NF-kappa B activation as well as TNF-mediated apoptosis. The protein has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. A20 is as a tumor suppressor and has been shown to protect MCF-7 breast carcinoma cells from TNF-induced apoptosis. High A20 expression levels were observed in more aggressive breast tumors (ER-negative, progesterone receptor-negative and high histological grade). These findings strongly suggest that A20 is a key protein involved in tamoxifen resistance.

UniProt: P21580

Pathways: Activation of Innate immune Response