SCN8A antibody (AA 251-314) (HRP)

Catalog No. ABIN719990

Product Details anti-SCN8A Antibody (HRP)

Target: SCN8A (Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A))

Binding Specificity: AA 251-314

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCN8A antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SCN8A/Nav1.6

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SCN8A

Target: SCN8A (Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A))

Alternative Name: SCN8A (SCN8A Products)

Background:

Synonyms: CerIII, hNa6/Scn8a voltage gated sodium channel, MED, Motor endplate disease, NaCh 6, NaCh6, Nav 1.6, Nbna1, PN 4, PN4, Scn8a, SCN8A_HUMAN, Sodium channel protein type 8 alpha subunit, Sodium channel protein type 8 subunit alpha, Sodium channel protein type VIII alpha subunit, Sodium channel protein type VIII subunit alpha, Sodium channel voltage gated type VIII alpha, Sodium channel voltage gated type VIII alpha polypeptide, Sodium channel voltage gated type VIII alpha subunit, Voltage gated sodium channel subunit alpha Nav1.6, Voltage-gated sodium channel subunit alpha Nav1.6.

Background: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation.

Gene ID: 6334

Pathways: Sensory Perception of Sound