BRAF antibody

Catalog No. ABIN7598850

This Rabbit Monoclonal antibody specifically detects BRAF in IHC (p). It exhibits reactivity toward Human.

Quick Overview for BRAF antibody (ABIN7598850)

Target: BRAF (B-Raf proto-oncogene, serine/threonine kinase (BRAF))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This BRAF antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: G11-G

Product Details anti-BRAF Antibody

Purpose: Anti-Braf

Specificity: Braf

Immunogen: Peptide derived from human B-raf surrounding the Val-600 residue (corresponds to Val 637 of mouse or rat B-raf)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 20 mM Tris-HCI, pH 8.0, Stabilizer: 20 mg/mL BSA, Preservative: 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: +2 °C to +8 °C

Target Details for BRAF

Target: BRAF (B-Raf proto-oncogene, serine/threonine kinase (BRAF))

Alternative Name: Braf

Background: B-raf proto-oncogene belongs to a large group of serine/threonine kinases of RAF family, involved in the transduction of mitogenic signals from the cell membrane to the nucleus. This protein kinase is frequently mutated in thyroid cancer and human melanomas, less frequently in other types of malignant tissues, including colorectal cancers, lung cancers and gliomas. Ninety percent of B-raf mutations are represented by B-raf V600-E mutation, presented by up to 500-fold increased activation in MEK/ERK signaling in tumor cells.

UniProt: P15056

Pathways: MAPK Signaling, RTK Signaling, Neurotrophin Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Hepatitis C, Autophagy