IFNB1 antibody

Catalog No. ABIN7670654

This Rat Monoclonal antibody specifically detects IFNB1 in ELISA (Capture). It exhibits reactivity toward Mouse.

Quick Overview for IFNB1 antibody (ABIN7670654)

Target: IFNB1 (Interferon, beta 1, Fibroblast (IFNB1))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This IFNB1 antibody is un-conjugated

Application: ELISA (Capture)

Clone: 4F9

Product Details anti-IFNB1 Antibody

Purpose: IFN-beta Monoclonal Antibody(Capture)

Purification: Protein A/G Purification

Immunogen: Recombinant Mouse IFN-beta protein expressed by Mammalian

Isotype: IgG1

Application Details

Application Notes: ELISA Capture 2-8 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Preservative: Without preservative

Handling Advice: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Expiry Date: 12 months

Target Details for IFNB1

Target: IFNB1 (Interferon, beta 1, Fibroblast (IFNB1))

Alternative Name: IFN-beta

Background: IFNB1,IFB,IFF,IFNB,Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli.Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways. Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor. Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss. IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth.

UniProt: P01575

Pathways: JAK-STAT Signaling, TCR Signaling, TLR Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Autophagy, Inflammasome