Recombinant PAI1 antibody (N-Term)

Catalog No. ABIN7857716

This Mouse Monoclonal antibody specifically detects PAI1 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for Recombinant PAI1 antibody (N-Term) (ABIN7857716)

Target: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PAI1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: RTJA6

Product Details anti-PAI1 Antibody

Binding Specificity: N-Term

Expression System: CHO Cells

Purpose: Recombinant Plasminogen Activator Inhibitor (Type 1) / PAI-1 (Breast Cancer Prognostic Marker) Antibody

Specificity: This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. The protein also functions as a component of innate antiviral immunity. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia.

Purification: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogen: Prokaryotic recombinant protein corresponding to a 250 amino acid portion of the N-terminus of the human PAI-1 molecule

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for PAI1

Target: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Alternative Name: Plasminogen Activator Inhibitor

Background:

endothelial plasminogen activator inhibitor serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 serpin E1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

A-431 cells. Human placenta, lung or breast cancer.

Molecular Weight: 50kDa

Gene ID: 5054

UniProt: P05121

Pathways: p53 Signaling, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration