SHP1 antibody (AA 395-595)

Catalog No. ABIN7864411

The Mouse Monoclonal anti-SHP1 antibody (Clone PTPN6-7543) (ABIN7864411) specifically detects SHP1 in IHC. The antibody is reactive with Human samples.

Quick Overview for SHP1 antibody (AA 395-595) (ABIN7864411)

Target: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SHP1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: PTPN6-7543

Product Details anti-SHP1 Antibody

Binding Specificity: AA 395-595

Purpose: Protein Tyrosine Phosphatase, non-receptor type 6 Antibody

Specificity: PTPN6, which is also designated as SHP-1, is expressed primarily in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. It maps to 12p13, a region commonly involved in leukemia-associated chromosomal abnormalities. SHP-1 plays a role in modulating intracellular signaling for various molecules. In T-cell lymphomas and other malignancies, SHP-1 phosphatase expression is lost, by a thus far undetermined mechanism. Preliminary studies suggest that it may be helpful in differentiating mantle/marginal zone lymphomas (SHP-1+) from follicular lymphomas (SHP-1 negative).

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa395-595) of human PTPN6 protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for SHP1

Target: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Alternative Name: Protein Tyrosine Phosphatase, non-receptor type 6

Background:

PTPN6, SHP1, protein tyrosine phosphatase, non-receptor type 6, HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, 70 kda SHP-1L protein, hematopoietic cell phosphatase, hematopoietic cell protein-tyrosine phosphatase, protein-tyrosine phosphatase 1C, PTPN6 / SHP

Human tonsil|lymph node or spleen.

Molecular Weight: 65kDa

Gene ID: 5777, 63489

UniProt: P29350

Pathways: JAK-STAT Signaling, TCR Signaling, TLR Signaling, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, BCR Signaling