Recombinant CD45RA antibody

Catalog No. ABIN7863313

The Rabbit Monoclonal anti-CD45RA antibody (Clone PTPRC-7019R) (ABIN7863313) specifically detects CD45RA in IHC and WB. The antibody is reactive with Human samples.

Quick Overview for Recombinant CD45RA antibody (ABIN7863313)

Target: CD45RA

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD45RA antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Clone: PTPRC-7019R

Product Details anti-CD45RA Antibody

Purpose: Recombinant CD45RA / LCA (B-Cell Marker) Antibody

Specificity: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human PTPRC protein

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for CD45RA

Target: CD45RA

Alternative Name: CD45RA

Background:

B220, CD45R, GP180, Leukocyte common antigen (LCA), Loc, Ly-5, Lyt-4, Protein tyrosine phosphatase receptor type C (PTPRC), Receptor-type tyrosine-protein phosphatase C, T200 glycoprotein

Jurkat, or GA-10 cells. Human tonsil or lymph node., Raji, Ramos, U-698

Molecular Weight: 180-220kDa

Gene ID: 5788, 654514

UniProt: P08575