Recombinant CD45RA antibody (Extracellular Domain)

Catalog No. ABIN7865502

The Rabbit Monoclonal anti-CD45RA antibody (Clone MSVA-045R) (ABIN7865502) specifically detects CD45RA in IHC. The antibody is reactive with Human samples.

Quick Overview for Recombinant CD45RA antibody (Extracellular Domain) (ABIN7865502)

Target: CD45RA

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD45RA antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: MSVA-045R

Product Details anti-CD45RA Antibody

Binding Specificity: AA 1-600, Extracellular Domain

Expression System: HEK-293 Cells

Purpose: Recombinant CD45RA / LCA (B-Cell Marker) Antibody

Specificity: CD45 is a family of single chain transmembrane glycoproteins, consisting of at least four isoforms which share a common large intracellular domain. Their extracellular domains are rod shaped, heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1q31-32.CD45 is exclusively expressed in haematolymphoid cells. Almost all haematolymphoid cells, including precursor cells and mature B- and T-lymphocytes, granulocytes, monocytes/histiocytes and interdigitating reticulum cells and follicular dendritic cells express CD45. This protein is detected in the large majority of haematolymphoid neoplasms, i.e., leukemias and malignant lymphomas. Overall, about 90 % of malignant lymphomas are CD45 positive.CD45 is an important marker in the primary tumor screening panel in order to identify haematolymphoid differentiation. Loss of CD45 in precursor B-cell neoplasms is a negative prognostic parameter.

Purification: Ab produced in HEK293 cell mammalian-based expression system.

Immunogen: Recombinant fragment (around aa1-600) of human PTPRC protein (extracellular domain)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for CD45RA

Target: CD45RA

Alternative Name: CD45RA

Background:

B220, CD45R, GP180, Leukocyte common antigen (LCA), Loc, Ly-5, Lyt-4, Protein tyrosine phosphatase receptor type C (PTPRC), Receptor-type tyrosine-protein phosphatase C, T200 glycoprotein

Tonsil: All lymphocytes and histiocytes must show a strong membranous CD45 staining.

Molecular Weight: 180-220kDa

Gene ID: 5788, 654514

UniProt: P08575