SIGMAR1 antibody (AA 1-154)

Catalog No. ABIN7868213

This Rabbit Polyclonal antibody specifically detects SIGMAR1 in WB, ELISA and IHC (p). It exhibits reactivity toward Human, Mouse, Rat and Monkey.

Quick Overview for SIGMAR1 antibody (AA 1-154) (ABIN7868213)

Target: SIGMAR1 (sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIGMAR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SIGMAR1 Antibody

Binding Specificity: AA 1-154

Purpose: Sigma1-receptor Antibody / SIGMAR1

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids G1-H154) was used as the immunogen for the Sigma1-receptor antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Sigma1-receptor antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Sigma1-receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SIGMAR1

Target: SIGMAR1 (sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1))

Alternative Name: Sigma1-receptor

Background: The sigma-1 receptor, one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor. In humans, the sigma-1 receptor is encoded by the SIGMAR1 gene. This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor, it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms.

UniProt: Q99720

Pathways: SARS-CoV-2 Protein Interactome