Recombinant SDHB antibody

Catalog No. ABIN7882381

The Rabbit Monoclonal anti-SDHB antibody is suitable to detect SDHB in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant SDHB antibody (ABIN7882381)

Target: SDHB (Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This SDHB antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: SDHB-6697R

Product Details anti-SDHB Antibody

Purpose: Recombinant SDHB Antibody (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: A synthetic peptide specific to human SDHB was used as the immunogen for the recombinant SDHB antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the recombinant SDHB antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the recombinant SDHB antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for SDHB

Target: SDHB (Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB))

Alternative Name: SDHB

Background: Succinate dehydrogenase B (SDHB) is an iron-sulfur subunit of mitochondrial complex II, a key component of the citric acid cycle and the electron transport chain, a respiratory complex that catalyzes the oxidation of succinate in the mitochondrial membrane. Many cancers are generally positive for SDHB, including renal cell carcinomas and gastrointestinal stromal tumors. A subset of RCC and GIST tumors that are associated with SDH mutations, Carney-Stratakis Syndrome or Carney Triad exhibit a loss of SDHB expression.

UniProt: P21912