BSCL2 antibody (AA 87-231) (APC)

Catalog No. ABIN7972582

The Rabbit Polyclonal anti-BSCL2 antibody is suitable to detect BSCL2 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for BSCL2 antibody (AA 87-231) (APC) (ABIN7972582)

Target: BSCL2 (Berardinelli-Seip Congenital Lipodystrophy 2 (Seipin) (BSCL2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BSCL2 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-BSCL2 Antibody (APC)

Binding Specificity: AA 87-231

Purpose: Anti-BSCL2/Seipin Antibody APC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human BSCL2/Seipin recombinant protein (Position: A87-P231).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for BSCL2

Target: BSCL2 (Berardinelli-Seip Congenital Lipodystrophy 2 (Seipin) (BSCL2))

Alternative Name: BSCL2

Background:

Background: Seipin is a protein that in humans is encoded by the BSCL2 gene. This gene encodes the multi-pass transmembrane protein protein seipin. This protein localizes to the endoplasmic reticulum and may be important for lipid droplet morphology. Mutations in this gene have been associated with congenital generalized lipodystrophy type 2 or Berardinelli-Seip syndrome, a rare autosomal recessive disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HNRNPUL2 (heterogeneous nuclear ribonucleoprotein U-like 2).

Gene Full Name: BSCL2 lipid droplet biogenesis associated, seipin

Gene ID: 26580

UniProt: Q96G97