HACE1 antibody (AA 75-170)
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- Target See all HACE1 Antibodies
- HACE1 (HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1))
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Binding Specificity
- AA 75-170
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Reactivity
- Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This HACE1 antibody is un-conjugated
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Application
- ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Cross-Reactivity
- Mouse
- Predicted Reactivity
- Human,Rat,Dog,Cow,Pig,Horse,Chicken
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human HACE1
- Isotype
- IgG
- Top Product
- Discover our top product HACE1 Primary Antibody
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- Application Notes
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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- Target
- HACE1 (HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1))
- Alternative Name
- Hace1 (HACE1 Products)
- Synonyms
- HACE1 antibody, 1700042J16Rik antibody, A730034A22Rik antibody, BC025474 antibody, HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 antibody, HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 L homeolog antibody, HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 antibody, HACE1 antibody, hace1 antibody, hace1.L antibody, Hace1 antibody
- Background
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Synonyms: E3 ubiquitin-protein ligase HACE1, HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1, HACE1, KIAA1320
Background: E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
- Gene ID
- 57531
- UniProt
- Q8IYU2
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