JAK1 antibody (pTyr1034)

Catalog No. ABIN8122377

The Rabbit Polyclonal anti-JAK1 antibody is suitable to detect JAK1 in samples from Human, Mouse and Rat. It has been validated for WB and IHC.

Quick Overview for JAK1 antibody (pTyr1034) (ABIN8122377)

Target: JAK1 (Janus Kinase 1 (JAK1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JAK1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-JAK1 Antibody

Binding Specificity: pTyr1034

Purpose: Jak1(Phospho Tyr1034/1035) Antibody

Specificity: This antibody detects endogenous levels of Human Mouse Rat Jak1(phospho-Tyr1034 or 1035)

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized phosho peptide around human Jak1(Tyr1034 and 1035)

Isotype: IgG

Application Details

Application Notes: WB 1:200-1000,IHC 1:50-300

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for JAK1

Target: JAK1 (Janus Kinase 1 (JAK1))

Alternative Name: Jak1

Background:

Synonyms: Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)

Background: This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],

Gene Name: JAK1 JAK1A JAK1B

Protein Name: Jak1(Tyr1034/1035)

Gene ID: 3716

UniProt: P23458

Pathways: JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Hepatitis C, Toll-Like Receptors Cascades, Unfolded Protein Response