JAK3 antibody (pTyr980)

Catalog No. ABIN8122384

The Rabbit Polyclonal anti-JAK3 antibody (ABIN8122384) specifically detects JAK3 in WB and IHC. The antibody is reactive with Human and Mouse samples.

Quick Overview for JAK3 antibody (pTyr980) (ABIN8122384)

Target: JAK3 (Janus Kinase 3 (JAK3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JAK3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-JAK3 Antibody

Binding Specificity: pTyr980

Purpose: Jak3 (Phospho Tyr980/981) Antibody

Specificity: This antibody detects endogenous levels of Human Mouse Jak3 (phospho-Tyr980 or 981)

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized phosho peptide around human Jak3 (Tyr980 and 981)

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000,IHC 1:50-300

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for JAK3

Target: JAK3 (Janus Kinase 3 (JAK3))

Alternative Name: Jak3

Background:

Synonyms: Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK)

Background: The protein encoded byThis gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008],

Gene Name: JAK3

Protein Name: Jak3 (Tyr980/981)

Gene ID: 3718

UniProt: P52333

Pathways: JAK-STAT Signaling, RTK Signaling, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus, Activated T Cell Proliferation, Unfolded Protein Response