HVCN1 antibody (C-Term)

Catalog No. ABIN783681

Product Details anti-HVCN1 Antibody

Target: HVCN1 (Hydrogen Voltage-Gated Channel 1 (HVCN1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HVCN1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antoibody detects HVCN1 / VSOP at C-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide near the carboxy terminus of human HVCN1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for HVCN1

Target: HVCN1 (Hydrogen Voltage-Gated Channel 1 (HVCN1))

Alternative Name: HVCN1 / VSOP (HVCN1 Products)

Synonyms: zgc:92181 antibody, HVCN1 antibody, VSOP antibody, vsx1 antibody, HV1 antibody, 0610039P13Rik antibody, AI450555 antibody, BTS antibody, Vsop antibody, mVSOP antibody, RGD1310788 antibody, hydrogen voltage-gated channel 1 antibody, hydrogen voltage gated channel 1 pseudogene antibody, hydrogen voltage gated channel 1 antibody, voltage-gated hydrogen channel 1 antibody, hydrogen voltage gated channel 1 L homeolog antibody, hvcn1 antibody, LOC452241 antibody, HVCN1 antibody, Hvcn1 antibody, hvcn1.L antibody

Background: HVCN1 (hydrogen voltage-gated channel 1), a voltage gated proton channel protein that is highly expressed in immune tissues, mediates the proton conductances required by phagocytic leukocytes for the oxidative burst that underlies microbial killing. HVCN1 moderates the voltage-dependent proton permeability of excitable membranes by allowing the flow of protons in accordance to their electrochemical gradient. HVCN1 is sensitive to zinc ions, and can be inhibited by them. HVCN1 may represent a new therapeutic target for B cell malignancies on continued signaling via the B cell antigen receptor.Synonyms: HV1, Hydrogen voltage-gated channel 1, Voltage sensor domain-only protein, Voltage-gated hydrogen channel 1

Gene ID: 84329

NCBI Accession: NP_001035196

UniProt: Q96D96

Pathways: Proton Transport