MGC83599 antibody, D15S1518E antibody, HsT16821 antibody, LIN-10 antibody, MGC:14091 antibody, MINT2 antibody, X11-BETA antibody, X11L antibody, X11-like antibody, XllL antibody, mXllL antibody, Mint2 antibody, amyloid beta precursor protein binding family A member 2 antibody, amyloid beta (A4) precursor protein-binding, family A, member 2 L homeolog antibody, amyloid beta (A4) precursor protein-binding, family A, member 2 antibody, APBA2 antibody, apba2.L antibody, Apba2 antibody
Background
APBA2, a member of the X11 protein family, is a phosphotyrosine-binding domain protein and is a neuronal adapter protein that interacts with amyloid precursor protein (APP) and neuritic plaques in the brains of patients with Alzheimer's disease. It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. APBA2 is believed to be involved in signal transduction processes and is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Recent reports suggest that it may also be a candidate gene for autism.Synonyms: Adapter protein X11beta, Amyloid beta A4 precursor protein-binding family A member 2, MINT2, Mint-2, Neuron-specific X11L protein, Neuronal Munc18-1-interacting protein 2, X11L