Mre11 antibody (pSer676) (AbBy Fluor® 555)
-
- Target See all Mre11 (MRE11A) Antibodies
- Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))
-
Binding Specificity
- pSer676
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This Mre11 antibody is conjugated to AbBy Fluor® 555
-
Application
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- Cross-Reactivity
- Human
- Predicted Reactivity
- Mouse,Rat,Dog
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic phosphopeptide derived from rat Mre11 around the phosphorylation site of Ser676
- Isotype
- IgG
- Top Product
- Discover our top product MRE11A Primary Antibody
-
-
- Application Notes
-
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
-
- Target
- Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))
- Alternative Name
- Mre11 (MRE11A Products)
- Synonyms
- wu:faa63d12 antibody, zgc:64018 antibody, Mre11 antibody, Mre11b antibody, ATLD antibody, HNGS1 antibody, MRE11 antibody, MRE11B antibody, MRE11 homolog A, double strand break repair nuclease antibody, MRE11 homolog, double strand break repair nuclease antibody, MRE11A homolog A, double strand break repair nuclease antibody, mre11a antibody, MRE11 antibody, Mre11a antibody
- Background
-
Synonyms: Mre 11, MRE 11a, MRE 11b, MRE11 homolog 1, MRE11 meiotic recombination 11 homolog A, MRE11a, MRE11b, AT like disease, Ataxia telangiectasia disorder like, Ataxia-telangiectasia disorder-like, ATLD, DNA recombination and repair protein, Double strand break repair protein MRE11A, Double-strand break repair protein MRE11A, endo/exonuclease Mre11. HNGS1, meiotic recombination S. cerevisiae 11 homolog A, meiotic recombination 11 homolog A S. cerevisiae, meiotic recombination 11 homolog A, M mMRE11A.MRE11_RAT
Background: Mre11 is a component of the MRN complex, which plays a critical role in double-strand break repair (DSB), DNA recombination, maintenance of telomere integrity, and meiosis. Mre11 has both single-strand endonuclease and double strand-specific 3'-5' exonuclease activities. Rad50, another component of the MRN complex, is postulated to bind to DNA ends and hold them in close proximity, thus facilitating searches for regions of sequence homology, and also possibly stimulating the activity of DNA ligases and/or restricting Mre11 activity. Mutations in Mre11 may cause breast cancer.
- Gene ID
- 4361
- Pathways
- DNA Damage Repair
-