GDF5 antibody (Alexa Fluor 647)

Catalog No. ABIN889869

Product Details anti-GDF5 Antibody (Alexa Fluor 647)

Target: GDF5 (Growth Differentiation Factor 5 (GDF5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GDF5 antibody is conjugated to Alexa Fluor 647

Application: Western Blotting (WB)

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CDMP1/GDF5

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GDF5

Target: GDF5 (Growth Differentiation Factor 5 (GDF5))

Alternative Name: Cdmp1 (GDF5 Products)

Synonyms: CDMP1 antibody, gdf antibody, gdf-5 antibody, GDF5 antibody, BDA1C antibody, BMP14 antibody, LAP4 antibody, OS5 antibody, SYM1B antibody, SYNS2 antibody, Cdmp-1 antibody, bp antibody, brp antibody, Cdmp1 antibody, growth differentiation factor 5 L homeolog antibody, growth differentiation factor 5 antibody, gdf5.L antibody, GDF5 antibody, Gdf5 antibody

Background:

Synonyms: Cartilage derived morphogenetic protein 1, Cartilage-derived morphogenetic protein 1, CDMP-1, CDMP1, GDF-5, Gdf 5, GDF5_HUMAN, Growth dferentiation factor 5, Growth/dferentiation factor 5, LAP4, Radotermin.

Background: Defects in GDF5 are the cause of acromesomelic chondrodysplasia Grebe type (AMDG) . Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMDG is an autosomal recessive form characterized by normal axial skeletons and missing or fused skeletal elements within the hands and feet.Defects in GDF5 are the cause of acromesomelic chondrodysplasia Hunter-Thompson type (AMDH). AMDH is an autosomal recessive form of dwarfism. Patients have limb abnormalities, with the middle and distal segments being most affected and the lower limbs more affected than the upper. AMDH is characterized by normal axial skeletons and missing or fused skeletal elements within the hands and feet.Defects in GDF5 are the cause of brachydactyly type C (BDC). BDC is an autosomal dominant disorder characterized by an abnormal shortness of the fingers and toes.

Gene ID: 8200