CRH antibody (AA 185-196) (Alexa Fluor 555)

Catalog No. ABIN892247

Product Details anti-CRH Antibody (Alexa Fluor 555)

Target: CRH (Corticotropin Releasing Hormone (CRH))

Binding Specificity: AA 185-196

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRH antibody is conjugated to Alexa Fluor 555

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Pig,Chicken,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CRF

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CRH

Target: CRH (Corticotropin Releasing Hormone (CRH))

Alternative Name: CRF (CRH Products)

Synonyms: CRF antibody, Gm1347 antibody, crf antibody, crh antibody, zgc:101864 antibody, CRH antibody, corticoliberin antibody, crhb antibody, crh.1-a antibody, crha antibody, corticotropin releasing hormone antibody, corticotropin releasing hormone b antibody, corticotropin releasing hormone S homeolog antibody, corticotropin releasing hormone L homeolog antibody, Crh antibody, CRH antibody, crhb antibody, crh antibody, crh.S antibody, crh.L antibody

Background:

Synonyms: Corticoliberin, Corticoliberin precursor, Corticotropin releasing factor, Corticotropin releasing hormone, Corticotropin releasing hormone deficiency included, crf, crh, crh deficiency included, corticoliberin preproprotein, CRF_HUMAN, Corticotropin-releasing factor, CRF, CRH, Corticotropin-releasing hormone.

Background: Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Apr 2010].

Gene ID: 1392

UniProt: P06850

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Activity, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Feeding Behaviour