FKBP8 antibody (AA 255-350) (HRP)
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- Target See all FKBP8 Antibodies
- FKBP8 (FK506 Binding Protein 8, 38kDa (FKBP8))
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Binding Specificity
- AA 255-350
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Reactivity
- Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This FKBP8 antibody is conjugated to HRP
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Cross-Reactivity
- Mouse, Rat
- Predicted Reactivity
- Human,Dog,Cow,Horse,Chicken
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human FKBP38
- Isotype
- IgG
- Top Product
- Discover our top product FKBP8 Primary Antibody
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- Application Notes
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handling Advice
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- FKBP8 (FK506 Binding Protein 8, 38kDa (FKBP8))
- Alternative Name
- FKBP38 (FKBP8 Products)
- Synonyms
- FKBP8 antibody, fkbp8 antibody, 38kDa antibody, FKBP-38 antibody, FKBP-8 antibody, Fkbp38 antibody, zgc:77672 antibody, FKBP38 antibody, FKBPr38 antibody, FK506 binding protein 8 antibody, FK506 binding protein 8 L homeolog antibody, FKBP8 antibody, fkbp8 antibody, Fkbp8 antibody, fkbp8.L antibody
- Background
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Synonyms: 38 kDa FK 506 binding protein homolog, 38 kDa FK506-binding protein, 38 kDa FKBP, 38 kDa antibody FK506 binding protein 8, FK506 binding protein 8, 38 kDa, FK506 binding protein, 38 kDa, FK506-binding protein 8, FKBP 38, FKBP-38, FKBP-8, FKBP8, FKBP8_HUMAN, FKBPR38, hFKBP38, Peptidyl-prolyl cis-trans isomerase FKBP8, PPIase FKBP8, Rotamase, Sam11.
Background: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27, may negatively regulate ZFYVE27 phosphorylation.Tissue specificity: Widely expressed. Highest levels seen in the brain.
- Gene ID
- 23770
- Pathways
- Autophagy
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