SETD7 antibody (AA 271-366) (Alexa Fluor 350)
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- Target See all SETD7 Antibodies
- SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))
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Binding Specificity
- AA 271-366
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SETD7 antibody is conjugated to Alexa Fluor 350
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Application
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Cross-Reactivity
- Human
- Predicted Reactivity
- Mouse,Rat,Dog,Cow,Pig,Horse
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Histone H4 K4 methyltransferase SETD7
- Isotype
- IgG
- Top Product
- Discover our top product SETD7 Primary Antibody
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- Application Notes
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))
- Alternative Name
- H3-K4-HMTase SETD7 (SETD7 Products)
- Synonyms
- KMT7 antibody, SET7 antibody, SET7/9 antibody, SET9 antibody, set7 antibody, zgc:101860 antibody, zgc:92330 antibody, 1600028F23Rik antibody, H3K4MT antibody, Set7 antibody, Set7/9 antibody, mKIAA1717 antibody, SET domain containing lysine methyltransferase 7 antibody, SET domain containing (lysine methyltransferase) 7 antibody, SETD7 antibody, setd7 antibody, Setd7 antibody
- Background
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Synonyms: FLJ21193, H3 K4 HMTase, H3-K4-HMTase SETD7, H4 lysine 4 specic, Histone H3 K4 methyltransferase, Histone H3 lysine 4 specic methyltransferase, Histone H3-K4 methyltransferase SETD7, Histone H4 K4 methyltransferase, Histone lysine N methyltransferase, Histone lysine N methyltransferase H3 lysine 4 specic SET7, Histone-lysine N-methyltransferase SETD7, KIAA1717, KMT7, Lysine methyltransferase, Lysine N-methyltransferase 7, OTTHUMP00000164543, OTTHUMP00000220049, SET 7, SET 7/9, SET 9, SET D7, SET domain containing lysine methyltransferase 7, SET domain containing protein 7, SET domain containing protein 8, SET domain-containing protein 7, SET7, SET7/9, SET9, Setd7, SETD7_HUMAN.
Background: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro.
- Gene ID
- 80854
- UniProt
- Q8WTS6
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