HRAS antibody (AA 101-152) (AbBy Fluor® 350)

Catalog No. ABIN901258

This Rabbit Polyclonal antibody specifically detects HRAS in WB, IF (cc) and IF (p). It exhibits reactivity toward Mouse and Rat.

Quick Overview for HRAS antibody (AA 101-152) (AbBy Fluor® 350) (ABIN901258)

Target: HRAS (HRas proto-oncogene, GTPase (HRAS))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HRAS antibody is conjugated to AbBy Fluor® 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-HRAS Antibody (AbBy Fluor® 350)

Binding Specificity: AA 101-152

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human H-ras

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for HRAS

Target: HRAS (HRas proto-oncogene, GTPase (HRAS))

Alternative Name: HRAS

Background:

Synonyms: c bas/has, c H ras, c has/bas p21 protein, C K RAS, c K ras2 protein, c Ki ras, c Kirsten ras protein, c ras Ki 2 protein, Cellular c Ki ras2 proto oncogene antibody G1III6 N ras, GTPase HRas, GTPase KRas, GTPase NRas, H Ras 1, H RasIDX, Ha Ras, HRAS 1, HRAS, HRAS1, K Ras 2, K ras, K ras p21 protein, K RAS2A, K RAS2B, K RAS4A, K RAS4B, KI RAS, Kirsten rat sarcoma 2 viral v Ki ras2 oncogene homolog, KRAS 1, KRAS 2, KRAS, KRAS1, KRAS2, N ras, N ras oncogene, Neuroblastoma RAS viral v ras oncogene homolog, NRAS 1, NRAS, NRAS1, NS3, Oncogene KRAS2, p21ras, PR310 c K ras oncogene antibody RASH 1, RASH1, RASK 2, RASK2, Transforming protein N Ras, Transforming protein p21, v Ha ras Harvey rat sarcoma viral oncogene homolog, v Ki ras2 Kirsten rat sarcoma 2 viral oncogene homolog, v Ki ras2 Kirsten rat sarcoma viral oncogene homolog, v ras neuroblastoma RAS viral oncogene homolog, RASH_HUMAN.

Background: This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq].

Gene ID: 3265

Pathways: p53 Signaling, MAPK Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Autophagy, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling, BCR Signaling