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MAP1LC3A/B antibody (AA 21-121) (AbBy Fluor® 488)

Reactivity: Human, Rat, Mouse, Rabbit WB, IF (cc), IF (p) Host: Rabbit Polyclonal AbBy Fluor® 488
Catalog No. ABIN904610
  • Target See all MAP1LC3A/B products
    MAP1LC3A/B (MAP1LC3A,B)
    Binding Specificity
    • 16
    • 14
    • 1
    • 1
    • 1
    AA 21-121
    Reactivity
    Human, Rat, Mouse, Rabbit
    Host
    • 32
    Rabbit
    Clonality
    • 32
    Polyclonal
    Conjugate
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This MAP1LC3A/B antibody is conjugated to AbBy Fluor® 488
    Application
    • 16
    • 14
    • 12
    • 12
    • 7
    • 6
    • 3
    • 2
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human, Mouse, Rabbit, Rat
    Predicted Reactivity
    Dog,Cow,Pig,Horse,Chicken
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human MAP1A/MAP1B LC3 B
    Isotype
    IgG
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    MAP1LC3A/B (MAP1LC3A,B)
    Alternative Name
    MAP1A/MAP1B LC3 A/B (MAP1LC3A/B Products)
    Synonyms
    ATG8F antibody, LC3B antibody, MAP1A/1BLC3 antibody, MAP1LC3B-a antibody, Map1lc3 antibody, Mpl3 antibody, zbs559 antibody, 1010001C15Rik antibody, Atg8 antibody, LC3b antibody, microtubule associated protein 1 light chain 3 beta antibody, microtubule-associated protein 1 light chain 3 beta antibody, MAP1LC3B antibody, Map1lc3b antibody
    Background

    Synonyms: MAP LC3 beta, LC3, Autophagy related protein LC3 A, Autophagy related protein LC3 B, Autophagy related ubiquitin like modier LC3 A, Autophagy related ubiquitin like modier LC3 B, MAP1 light chain 3 like protein 1, MAP1 light chain 3 like protein 2, MAP1A/1B light chain 3 A, MAP1A/1B light chain 3 B, MAP1A/1BLC3, MAP1A/MAP1B LC3 A, MAP1A/MAP1B LC3 B, MAP1ALC3, MAP1BLC3, MAP1LC3A, MAP1LC3B, Microtubule associated protein 1 light chain 3 alpha, Microtubule associated protein 1 light chain 3 beta, Microtubule associated proteins 1A/1B light chain 3, Microtubule associated proteins 1A/1B light chain 3A, Microtubule associated proteins 1A/1B light chain 3B.microtubule-associated proteins 1A/1B light chain 3 beta 2

    Background: A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. LC3, a ubiquitin-like modifier protein, is the human homolog of yeast Apg8 and is involved in the formation of autophagosomal vacuoles, called autophagosomes. LC3 is expressed as 3 splice variants (LC3A, LC3B and LC3C), which exhibit different tissue distributions and are processed into cytosolic and autophagosomal membrane-bound forms, termed LC3-I and LC3-II, respectively. A disruption to the autophagic process is now associated with the progression of several cancers, neurodegenerative disorders and cardiac pathologies, where LC3 is widely employed as a marker for autophagy.

    Gene ID
    81631, 84557
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