MLXIPL antibody (AA 81-180) (Alexa Fluor 350)

Catalog No. ABIN919907

Product Details anti-MLXIPL Antibody (Alexa Fluor 350)

Target: MLXIPL (MLX Interacting Protein-Like (MLXIPL))

Binding Specificity: AA 81-180

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLXIPL antibody is conjugated to Alexa Fluor 350

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human WBSCR14/ChREBP

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for MLXIPL

Target: MLXIPL (MLX Interacting Protein-Like (MLXIPL))

Alternative Name: WBSCR14 (MLXIPL Products)

Synonyms: ChREBP antibody, MLXIPL antibody, CHREBP antibody, MIO antibody, MONDOB antibody, WBSCR14 antibody, WS-bHLH antibody, bHLHd14 antibody, Wbscr14 antibody, MLX interacting protein-like antibody, MLX interacting protein like antibody, MLXIPL antibody, Mlxipl antibody

Background:

Synonyms: ChREBP, bHLHd14, Carbohydrate responsive element binding protein, MIO, MLX interacting protein like, Mlx interactor, MLXIPL, MONDOB, WBSCR 14, WBSCR14, Williams Beuren syndrome chromosome region 14, Williams Beuren syndrome chromosome region 14 protein, WS basic helix loop helix leucine zipper protein, WS bHLH, MLXPL_HUMAN.

Background: ChREBP (Carbohydrate responsive element binding protein) is a transcription factor playing a critical role in the nutrient and hormonal regulation of genes encoding enzymes of glucose metabolism and lipogenesis pathways. It contains several domains including a nuclear localization signal (NLS) near the N-terminus, polyproline domains, a basic helix-loop-helix leucine zipper (b/HLH/Zip) and a leucine zipper like (zip-like) domain.ChREBP is ubiquitously detected in various tissues, with highest expression in liver, kidney and white and brown adipose tissue. Under basal conditions ChREBP is localized in the cytosol, translocating into the nucleus upon high glucose stimulation following its dephosphorylation of serine 196.

Gene ID: 51085

Pathways: Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process