Osteoprotegerin antibody (N-Term)

Catalog No. ABIN925985

Product Details anti-Osteoprotegerin Antibody

Target: Osteoprotegerin (TNFRSF11B) (Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Osteoprotegerin antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Mouse (Murine), Rat (Rattus), Pig (Porcine), Rabbit, Dog (Canine)

Immunogen: TNFRSF11 B antibody was raised in rabbit using the N terminal of TNFRSF11 as the immunogen

Application Details

Application Notes: WB: 1.25 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

TNFRSF11B Blocking Peptide, catalog no. 33R-4849, is also available for use as a blocking control in assays to test for specificity of this TNFRSF11B antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 100 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

References for anti-Osteoprotegerin antibody (ABIN925985)

Hendrijantini, Suisan, Megantara, Tumali, Kuntjoro, Ari, Sitalaksmi, Hong: "Bone Remodeling in Mandible of Wistar Rats with Diabetes Mellitus and Osteoporosis." in: European journal of dentistry, (2022) (PubMed).

Target Details for Osteoprotegerin

Target: Osteoprotegerin (TNFRSF11B) (Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B))

Alternative Name: TNFRSF11B (TNFRSF11B Products)

Synonyms: CD254 antibody, ODF antibody, OPGL antibody, OPTB2 antibody, RANKL antibody, TRANCE antibody, hRANKL2 antibody, sOdf antibody, OCIF antibody, OPG antibody, TR1 antibody, Opg antibody, ocif antibody, opg antibody, tr1 antibody, TNF superfamily member 11 antibody, TNF receptor superfamily member 11b antibody, tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) antibody, TNF receptor superfamily member 11B antibody, tumor necrosis factor receptor superfamily member 11b S homeolog antibody, tumor necrosis factor receptor superfamily, member 11b antibody, TNFSF11 antibody, TNFRSF11B antibody, Tnfrsf11b antibody, tnfrsf11b.S antibody

Target Type: Chemical

Background: TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand (TNFSF11/OPGL), both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. Synonyms: Polyclonal TNFRSF11B antibody, Anti-TNFRSF11B antibody, tumor necrosis factor receptor superfamily, member 11b, osteoprotegerin antibody.