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Insulin Receptor antibody (Middle Region)

INSR Reactivity: Human, Mouse, Rat, Dog, Rabbit, Zebrafish (Danio rerio), Xenopus laevis WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN926933
  • Target See all Insulin Receptor (INSR) Antibodies
    Insulin Receptor (INSR)
    Binding Specificity
    • 17
    • 16
    • 14
    • 12
    • 9
    • 8
    • 8
    • 7
    • 6
    • 6
    • 5
    • 5
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    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 172
    • 96
    • 80
    • 16
    • 14
    • 9
    • 8
    • 7
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog, Rabbit, Zebrafish (Danio rerio), Xenopus laevis
    Host
    • 169
    • 23
    • 3
    • 1
    Rabbit
    Clonality
    • 161
    • 35
    Polyclonal
    Conjugate
    • 117
    • 17
    • 16
    • 8
    • 7
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Insulin Receptor antibody is un-conjugated
    Application
    • 144
    • 86
    • 56
    • 27
    • 16
    • 15
    • 15
    • 15
    • 13
    • 13
    • 8
    • 5
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Cross-Reactivity
    Mouse (Murine), Rat (Rattus), Dog (Canine), Rabbit, Zebrafish (Brachydanio rerio), Frog
    Purification
    Purified
    Immunogen
    INSR antibody was raised in rabbit using the middle region of INSR as the immunogen
    Top Product
    Discover our top product INSR Primary Antibody
  • Application Notes
    WB: 0.2-1 µg/mL
    Optimal conditions should be determined by the investigator.
    Comment

    INSR Blocking Peptide, catalog no. 33R-8809, is also available for use as a blocking control in assays to test for specificity of this INSR antibody

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Concentration
    Lot specific
    Buffer
    Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 4 °C, following reconstitution, aliquot and store at -20 °C.
  • Target
    Insulin Receptor (INSR)
    Alternative Name
    INSR (INSR Products)
    Synonyms
    CD220 antibody, HHF5 antibody, 4932439J01Rik antibody, D630014A15Rik antibody, IR antibody, IR-A antibody, IR-B antibody, 18402 antibody, CG18402 antibody, DIHR antibody, DILR antibody, DIR antibody, DIRH antibody, DIRbeta antibody, DInR antibody, DInr antibody, Dir-a antibody, Dir-b antibody, Dmel\\CG18402 antibody, INR antibody, INS antibody, Inr antibody, Inr-alpha antibody, Inr-beta antibody, InsR antibody, dINR antibody, dIR antibody, dIRH antibody, dInR antibody, dInr antibody, dInsR antibody, dinr antibody, dir antibody, er10 antibody, inr antibody, insulin/insulin-like growth factor receptor antibody, l(3)05545 antibody, l(3)93Dj antibody, l(3)er10 antibody, lnR antibody, ir-A antibody, CTK-1 antibody, ir antibody, INSR antibody, NV14476 antibody, cd220 antibody, hhf5 antibody, insulin receptor antibody, Insulin-like receptor antibody, insulin receptor L homeolog antibody, INSR antibody, Insr antibody, InR antibody, LOC100122567 antibody, LOC100451802 antibody, insr.L antibody
    Background
    This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. INSR mediates the metabolic functions of insulin. INSR binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). INSR can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. When present in a hybrid receptor with IGF1R, it binds IGF1. Synonyms: Polyclonal INSR antibody, Anti-INSR antibody, insulin receptor antibody, CD220 antibody, HHF5 antibody.
    Pathways
    NF-kappaB Signaling, RTK Signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity
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