TWEAK antibody (N-Term)

Catalog No. ABIN926993

Product Details anti-TWEAK Antibody

Target: TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TWEAK antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Mouse (Murine), Dog (Canine)

Purification: Purified

Immunogen: TNFSF12 antibody was raised in rabbit using the N terminal of TNFSF12 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

TNFSF12 Blocking Peptide, catalog no. 33R-7519, is also available for use as a blocking control in assays to test for specificity of this TNFSF12 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for TWEAK

Target: TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))

Alternative Name: TNFSF12 (TNFSF12 Products)

Synonyms: APO3L antibody, DR3LG antibody, TWEAK antibody, Apo3l antibody, Dr3l antibody, Dr3lg antibody, Tweak antibody, TNF superfamily member 12 antibody, tumor necrosis factor (ligand) superfamily, member 12 antibody, TNFSF12 antibody, Tnfsf12 antibody

Background: TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Synonyms: Polyclonal TNFSF12 antibody, Anti-TNFSF12 antibody, tumor necrosis factor, ligand superfamily, member 12 antibody.

Pathways: Apoptosis