PSMD10 antibody (N-Term)

Catalog No. ABIN928857

Product Details anti-PSMD10 Antibody

Target: PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))

Binding Specificity: N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMD10 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Mouse (Murine)

Purification: Purified

Immunogen: Psmd10 antibody was raised in rabbit using the N terminal of Psmd10 as the immunogen

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Comment:

Psmd10 Blocking Peptide, catalog no. 33R-4354, is also available for use as a blocking control in assays to test for specificity of this Psmd10 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for PSMD10

Target: PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))

Alternative Name: Psmd10 (PSMD10 Products)

Synonyms: gankyrin antibody, zgc:109707 antibody, dJ889N15.2 antibody, p28 antibody, p28(GANK) antibody, AW554874 antibody, p28Gank antibody, proteasome 26S subunit, non-ATPase 10 antibody, proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 antibody, psmd10 antibody, PSMD10 antibody, Psmd10 antibody

Background: Psmd10 acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly,Psmd10 is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module By similarity.Psmd10 acts as an oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression of this gene is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Psmd10 regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Synonyms: Polyclonal Psmd10 antibody, Anti-Psmd10 antibody, proteasome, prosome, macropain 26S subunit, non-ATPase, 10 antibody, AW554874 antibody.

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Ubiquitin Proteasome Pathway