PEN2 antibody (C-Term)

Catalog No. ABIN929230

Product Details anti-PEN2 Antibody

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PEN2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Purified

Immunogen: PSENEN antibody was raised in rabbit using the C terminal of PSENEN as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

PSENEN Blocking Peptide, catalog no. 33R-8714, is also available for use as a blocking control in assays to test for specificity of this PSENEN antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for PEN2

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Alternative Name: PSENEN (PSENEN Products)

Synonyms: MSTP064 antibody, PEN-2 antibody, PEN2 antibody, Psenen antibody, ACYPI006208 antibody, 1700023M09Rik antibody, Pen-2 antibody, RGD1312037 antibody, CG33198 antibody, Dmel\\CG33198 antibody, anon-AE003800.1 antibody, dPen-2 antibody, psenen antibody, pen-2 antibody, pen2 antibody, zgc:109727 antibody, presenilin enhancer gamma-secretase subunit antibody, presenilin enhancer 2 antibody, presenilin enhancer gamma secretase subunit antibody, Gamma-secretase subunit pen-2 antibody, presenilin enhancer antibody, presenilin enhancer gamma secretase subunit S homeolog antibody, PSENEN antibody, PEN2 antibody, Psenen antibody, pen-2 antibody, psenen.S antibody, psenen antibody

Background: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Synonyms: Polyclonal PSENEN antibody, Anti-PSENEN antibody, presenilin enhancer 2 homolog, C. elegans antibody, MDS033 antibody, MSTP064 antibody, PEN-2 antibody, PEN2 antibody.

Pathways: Notch Signaling, Neurotrophin Signaling Pathway