PCSK2 antibody (Middle Region)

Catalog No. ABIN929268

Product Details anti-PCSK2 Antibody

Target: PCSK2 (Proprotein Convertase Subtilisin/kexin Type 2 (PCSK2))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCSK2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Purified

Immunogen: PCSK2 antibody was raised in rabbit using the middle region of PCSK2 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

PCSK2 Blocking Peptide, catalog no. 33R-4799, is also available for use as a blocking control in assays to test for specificity of this PCSK2 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for PCSK2

Target: PCSK2 (Proprotein Convertase Subtilisin/kexin Type 2 (PCSK2))

Alternative Name: PCSK2 (PCSK2 Products)

Synonyms: NEC 2 antibody, NEC-2 antibody, NEC2 antibody, PC2 antibody, SPC2 antibody, PCSK2 antibody, 6330411F23Rik antibody, AI839700 antibody, Nec-2 antibody, Nec2 antibody, Phpp-2 antibody, pc2 antibody, nec2 antibody, spc2 antibody, pcsk2 antibody, pcsk2-A antibody, proprotein convertase subtilisin/kexin type 2 antibody, proprotein convertase subtilisin/kexin type 2 L homeolog antibody, PCSK2 antibody, pcsk2 antibody, Pcsk2 antibody, pcsk2.L antibody

Background: This gene encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in hormone biosynthesis by processing a variety of prohormones including proinsulin, proopiomelanocortin and proluteinizing-hormone-releasing hormone. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Synonyms: Polyclonal PCSK2 antibody, Anti-PCSK2 antibody, proprotein convertase subtilisin/kexin type 2 antibody, NEC2 antibody, PC2 antibody, SPC2 antibody.

Pathways: Peptide Hormone Metabolism, cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity