AIM2 antibody (AA 1-343)

Catalog No. ABIN948806

The Rabbit Polyclonal anti-AIM2 antibody has been validated for WB and IP. It is suitable to detect AIM2 in samples from Human. There is 1 publication available.

Quick Overview for AIM2 antibody (AA 1-343) (ABIN948806)

Target: AIM2 (Absent in Melanoma 2 (AIM2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AIM2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-AIM2 Antibody

Binding Specificity: AA 1-343

Purpose: Rabbit polyclonal antibody raised against a full-length human AIM2 protein.

Sequence: MESKYKEILL LTGLDNITDE ELDRFKFFLS DEFNIATGKL HTANRIQVAT LMIQNAGAVS AVMKTIRIFQ KLNYMLLAKR LQEEKEKVDK QYKSVTKPKP LSQAEMSPAA SAAIRNDVAK QRAAPKVSPH VKPEQKQMVA QQESIREGFQ KRCLPVMVLK AKKPFTFETQ EGKQEMFHAT VATEKEFFFV KVFNTLLKDK FIPKRIIIIA RYYRHSGFLE VNSASRVLDA ESDQKVNVPL NIIRKAGETP KINTLQTQPL GTIVNGLFVV QKVTEKKKNI LFDLSDNTGK MEVLGVRNED TMKCKEGDKV RLTFFTLSKN GEKLQLTSGV HSTIKVIKAK KKT

Cross-Reactivity: Human

Characteristics: Antibody reactive against mammalian transfected lysate.

Immunogen: AIM2 (NP_004824.1, 1 a.a. ~ 343 a.a) full-length human protein.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: No additive

Preservative: Without preservative

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-AIM2 antibody (ABIN948806)

Adamczak, de Rivero Vaccari, Dale, Brand, Nonner, Bullock, Dahl, Dietrich, Keane: "Pyroptotic neuronal cell death mediated by the AIM2 inflammasome." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 34, Issue 4, pp. 621-9, (2014) (PubMed).

Target Details for AIM2

Target: AIM2 (Absent in Melanoma 2 (AIM2))

Alternative Name: AIM2

Background: Full Gene Name: absent in melanoma 2
Synonyms: PYHIN4

Gene ID: 9447

NCBI Accession: NM_004833

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome