Rabbit anti-Human IgG (Heavy & Light Chain) Antibody

Catalog No. ABIN952836

Product Details

Target: IgG

Binding Specificity: Heavy & Light Chain

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Application: Immunoprecipitation (IP), Immunodiffusion (ID)

Characteristics: The antiserum of individual host animals was monitored for titre and specificity before pooling into uniform high titre lots.
Against NHS: Single band at all dilutions up to 1/1024.
Against NMS: No bands at a dilution of 1/4.
Against Human IgG (5 mg/mL): Lot 0128 produced a single band homogeneous with a single band from NHS dilutions of 1/4 and 1/8.

Purification: Serum

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details

Target: IgG

Abstract: IgG Products

Target Type: Antibody

Background: IgG is a monomeric immunoglobulin, built of two heavy chains gamma and two light chains. Each molecule has two antigen binding sites. This is the most abundant immunoglobulin and is approximately equally distributed in blood and in tissue liquids, constituting 75 % of serum immunoglobulins in humans. This is the only isotype that can pass through the human placenta, thereby providing protection to the fetus in its first weeks of life before its own immune system has developed. It can bind to many kinds of pathogens, for example viruses, bacteria, and fungi, and protects the body against them by complement activation (classic pathway), opsonization for phagocytosis and neutralisation of their toxins. There are 4 subclasses: IgG1 (66 %), IgG2 (23 %), IgG3 (7 %) and IgG4 (4 %).Synonyms: Human Immunoglobulin G