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SUN2 antibody (Middle Region)
SUN2
Reactivity: Human
WB, EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-SUN2 Antibody
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Target
See all SUN2 Antibodies
SUN2
(Sad1 and UNC84 Domain Containing 2 (SUN2))
Binding Specificity
All epitopes for SUN2 antibodies
AA 236-265, Middle Region
Reactivity
All reactivities for SUN2 antibodies
Human
Host
All hosts for SUN2 antibodies
Rabbit
Clonality
All clonalities for SUN2 antibodies
Polyclonal
Conjugate
All conjugates for SUN2 antibodies
This SUN2 antibody is un-conjugated
Application
All applications for SUN2 antibodies
Western Blotting (WB), Enzyme Immunoassay (EIA)
Specificity
This antibody detects UNC84B (Center).
Cross-Reactivity (Details)
Species reactivity (tested):Human
Purification
Protein A column followed by peptide affinity purification
Immunogen
KLH conjugated synthetic peptide between 236-265 amino acids from the Central region of human UNC84B
Isotype
Ig Fraction
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
0.25 mg/mL
Buffer
PBS with 0.09 % (W/V) sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Target Details for SUN2
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Target
SUN2
(Sad1 and UNC84 Domain Containing 2 (SUN2))
Alternative Name
SUN2 / UNC84B (SUN2 Products )
Synonyms
UNC84B antibody, B230369L08Rik antibody, C030011B15 antibody, Unc84b antibody, RGD1563141 antibody, Sad1 and UNC84 domain containing 2 antibody, SUN2 antibody, Sun2 antibody
Background
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1, MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).Synonyms: FRIGG, KIAA0668, Protein unc-84 homolog B, RAB5IP, Rab5-interacting protein, Rab5IP, SUN domain-containing protein 2, Sad1/unc-84 protein-like 2
Gene ID
25777
NCBI Accession
NP_001186508
Pathways
Maintenance of Protein Location , SARS-CoV-2 Protein Interactome , The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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