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ESRP1 antibody

ESRP1 Reactivity: Mouse WB Host: Mouse Monoclonal 27H12-F3-H5 unconjugated
Catalog No. ABIN964639
  • Target See all ESRP1 Antibodies
    ESRP1 (Epithelial Splicing Regulatory Protein 1 (ESRP1))
    Reactivity
    • 23
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Mouse
    Host
    • 21
    • 3
    Mouse
    Clonality
    • 23
    • 1
    Monoclonal
    Conjugate
    • 12
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ESRP1 antibody is un-conjugated
    Application
    • 17
    • 8
    • 7
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Specificity
    This product is an IgG fraction antibody purified from tissue culture supernatant by Protein-A chromatography followed by extensive dialysis against the buffer stated above. This antibody reacts with mouse Esrp-1 protein.  A BLAST analysis of the immunizing protein sequence shows 100% homology with Esrp-1 from mouse and a 91% sequence homology with Esrp-1 from human, pig, rat, opossum, horse, cattle, panda, dog, and chimpanzee .  The binding epitope of this monoclonal antibody has not been mapped.
    Characteristics
    Epithelial splicing regulatory protein 1 (Esrp-1) is an mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. It specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2, and also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Esrp-1 acts by directly binding specific sequences in mRNAs. It binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
    Purification
    purified
    Sterility
    Sterile filtered
    Immunogen
    Anti-Esrp-1 was produced by repeated immunizations of full length recombinant mouse Esrp-1 fusion protein.
    Immunogen Type: RecombinantProtein
    Clone
    27H12-F3-H5
    Isotype
    IgG2b kappa
    Top Product
    Discover our top product ESRP1 Primary Antibody
  • Application Notes
    This protein-A purified antibody has been tested for use western blotting.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 75.5 kDa in size corresponding to Esrp-1 by western blotting in the appropriate cell lysate or extract.
    Comment

    Gene Name: Esrp1

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.0 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is three (3) months from date of opening.
    Expiry Date
    3 months
  • Kim, Kim, Oh, Hong, Kim: "Pressure-overload cardiac hypertrophy is associated with distinct alternative splicing due to altered expression of splicing factors." in: Molecules and cells, Vol. 37, Issue 1, pp. 81-7, (2014) (PubMed).

    Warzecha, Jiang, Amirikian, Dittmar, Lu, Shen, Guo, Xing, Carstens: "An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition." in: The EMBO journal, Vol. 29, Issue 19, pp. 3286-300, (2010) (PubMed).

  • Target
    ESRP1 (Epithelial Splicing Regulatory Protein 1 (ESRP1))
    Alternative Name
    Esrp-1 (ESRP1 Products)
    Synonyms
    rbm35a antibody, RBM35A antibody, RMB35A antibody, 2210008M09Rik antibody, A630065D16 antibody, BC031468 antibody, Rbm35a antibody, RGD1560481 antibody, wu:fi28a07 antibody, zgc:154050 antibody, epithelial splicing regulatory protein 1 antibody, epithelial splicing regulatory protein 1 L homeolog antibody, ESRP1 antibody, esrp1.L antibody, Esrp1 antibody, esrp1 antibody
    Background
    Epithelial splicing regulatory protein 1 (Esrp-1) is an mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. It specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2, and also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Esrp-1 acts by directly binding specific sequences in mRNAs. It binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
    Synonyms: Rbm35a, Epithelial splicing regulatory protein 1, RNA-binding protein 35A, RNA-binding motif protein 35A.
    Gene ID
    207920
    NCBI Accession
    NP_918944
    UniProt
    Q3US41
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