STAT6 antibody (Internal Region, pTyr641)
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- Target See all STAT6 Antibodies
- STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
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Binding Specificity
- Internal Region, pTyr641
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This STAT6 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Specificity
- This affinity purified antibody is directed against human STAT6 pY641 protein. The product was affinity purified from monospecific antiserum by immunoaffinity chromatography. A BLAST analysis was used to suggest cross-reactivity with STAT6 pY641 protein from human at 100% based on homology with the immunizing sequence. Reactivity against homologues from other sources is not known.
- Characteristics
- Anti-STAT6 phospho Y641 Antibody is ideal to study STAT6. STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT6 is involved in interleukin-4 signaling. It interacts with NCOA1 via its C-terminal LXXLL motif. Further it induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Following stimulation by IL-4 and IL-3, Stat6 is activated via phosphorylation at Tyr641 and translocates to the nucleus where it regulates cytokine-induced gene expression. STAT6 research areas include Immunology, Signal Transduction and Chromatin & Nuclear Signaling.
- Purification
- affinity purified
- Sterility
- Sterile filtered
- Immunogen
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STAT6 phospho Y641 Antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to residues surrounding Y641 of human STAT6 protein.
Immunogen Type: Peptide - Isotype
- IgG
- Top Product
- Discover our top product STAT6 Primary Antibody
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- Application Notes
- This affinity purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 94.1kDa in size corresponding to STAT6 pY641 protein by western blotting in the appropriate cell lysate or extract.
- Comment
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Gene Name: STAT6
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.13 mg/mL
- Buffer
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store vial at 4° C prior to opening. This product is stable at 4° C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
- Expiry Date
- 12 months
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- Target
- STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
- Alternative Name
- STAT6 (STAT6 Products)
- Synonyms
- D12S1644 antibody, IL-4-STAT antibody, STAT6B antibody, STAT6C antibody, signal transducer and activator of transcription 6 antibody, signal transducer and activator of transcription 6-like antibody, STAT6 antibody, Stat6 antibody, LOC100859543 antibody
- Background
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Anti-STAT6 phospho Y641 Antibody is ideal to study STAT6. STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT6 is involved in interleukin-4 signaling. It interacts with NCOA1 via its C-terminal LXXLL motif. Further it induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Following stimulation by IL-4 and IL-3, Stat6 is activated via phosphorylation at Tyr641 and translocates to the nucleus where it regulates cytokine-induced gene expression. STAT6 research areas include Immunology, Signal Transduction and Chromatin & Nuclear Signaling.
Synonyms: Signal transducer and activator of transcription 6 antibody, IL-4 Stat antibody - Gene ID
- 6778
- NCBI Accession
- NP_001171549
- UniProt
- P42226
- Pathways
- JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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