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BCL10 antibody
BCL10
Reactivity: Human
WB, IHC, ELISA
Monoclonal
unconjugated
Product Details anti-BCL10 Antibody
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Target
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BCL10
(B-Cell CLL/lymphoma 10 (BCL10))
Reactivity
All reactivities for BCL10 antibodies
Human
Host
Please inquire
Clonality
All clonalities for BCL10 antibodies
Monoclonal
Conjugate
All conjugates for BCL10 antibodies
This BCL10 antibody is un-conjugated
Application
All applications for BCL10 antibodies
Western Blotting (WB), Immunohistochemistry (IHC), ELISA
Specificity
Ni-NTA purified recombinant human BCL-10 expressed in E. Coli strain BL21 (DE3).
Purification
Antibodies are purified by protein A affinity chromatography
Isotype
IgG1
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Alternatives
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Application Details
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Application Notes
IHC(P): Dilution 1: 100- 1: 500 IHC(F): Dilution 1: 200- 1: 1000 Western blot: Dilution 1: 2000- 1: 5000 ELISA: Propose dilution 1: 10000. Determining optimal working dilutions by titration test.
Restrictions
For Research Use only
Handling
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Storage
-20 °C
References for anti-BCL10 antibody (ABIN965650)
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Cahill : "Vasoconstrictor responsiveness of portal hypertensive vessels. " in: Clinical science (London, England : 1979) , Vol. 96 , Issue 1 , pp. 3-4 , (1999 ) (PubMed ).
Target Details for BCL10
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Target
BCL10
(B-Cell CLL/lymphoma 10 (BCL10))
Alternative Name
BCL-10 (BCL10 Products )
Synonyms
CARMEN antibody, CIPER antibody, CLAP antibody, c-E10 antibody, mE10 antibody, BCL10 antibody, AI132454 antibody, BCL-10 antibody, C81403 antibody, ME10 antibody, cE10 antibody, bcl10 antibody, B-cell CLL/lymphoma 10 antibody, B-cell lymphoma/leukemia 10-like antibody, B cell leukemia/lymphoma 10 antibody, B-cell lymphoma/leukemia 10 antibody, BCL10 antibody, Bcl10 antibody, bcl10 antibody, LOC100223183 antibody
Background
Bcl-10 is a 31kDa protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
Gene ID
8915
Pathways
TCR Signaling , Fc-epsilon Receptor Signaling Pathway , Activation of Innate immune Response , Positive Regulation of Immune Effector Process , Production of Molecular Mediator of Immune Response , Tube Formation , Positive Regulation of Endopeptidase Activity , BCR Signaling , Ubiquitin Proteasome Pathway , S100 Proteins
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