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APH1B Products

(Anterior Pharynx Defective 1 Homolog B (Aph1b))

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This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011].

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Featured APH1B Categories

APH1B Antibodies

High quality antibodies with extensive validation data.

APH1B Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended APH1B Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN7139847
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, ELISA, IF (p), IF (cc), IHC (fro), IHC (p), ICC
Validations
  • (1)
Cat. No. ABIN1386275
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN7139850
Quantity 100 μL
Datasheet Datasheet

Recommended APH1B ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6976100
Quantity 96 tests
Datasheet Datasheet

Recommended APH1B Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3104477
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3125756
Quantity 1 mg
Datasheet Datasheet
Reactivity C. elegans, Human, Mouse, Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN2747265
Quantity 5 applications
Datasheet Datasheet

Latest Publications for our APH1B products

Hu, Zeng, Li, Meyer, Cui, Xu: "Nicastrin is required for APP but not Notch processing, while Aph-1 is dispensable for processing of both APP and Notch." in: Journal of neurochemistry, (2015) (PubMed).

Schmitz, Wulf, Signore, Schulz-Schaeffer, Kermer, Bähr, Wouters, Zafar, Zerr: "Impact of the cellular prion protein on amyloid-? and 3PO-tau processing." in: Journal of Alzheimer's disease : JAD, Vol. 38, Issue 3, pp. 551-65, (2013) (PubMed).

Synonyms and alternative names related to APH1B

aph-1 homolog B, gamma-secretase subunit (APH1B), aph-1 homolog B, gamma secretase subunit (Aph1b), aph1 homolog B, gamma secretase subunit (Aph1b), 2310057K14Rik, APH-1B, APH-1B', Aph1c, PRO1328, PSFL, TAAV688

Protein level used designations for APH1B

  • anterior pharynx defective 1 homolog B
  • aph-1beta
  • gamma-secretase subunit APH-1B
  • anterior pharynx defective 1b homolog
  • APH-1b
  • APH1B homolog
  • anterior pharynx defective 1c homolog
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