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Caspase 8 Proteins

(Caspase 8 (CASP8))
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008].
Caspase 8 Protein (CASP8) (AA 217-374) (His tag) Caspase 8 Protein (CASP8) (AA 217-374) (His tag) Caspase 8 Protein (CASP8) (AA 217-374) (His tag) (ABIN7122169)

CASP8 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA

Caspase 8 Protein (CASP8) (AA 200-496) (His tag) Caspase 8 Protein (CASP8) (AA 200-496) (His tag) Caspase 8 Protein (CASP8) (AA 200-496) (His tag) (ABIN7122170)

CASP8 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA

Caspase 8 Protein (CASP8) (AA 388-480) (His tag) Caspase 8 Protein (CASP8) (AA 388-480) (His tag) Caspase 8 Protein (CASP8) (AA 388-480) (His tag) (ABIN3132327)

Crystallography grade CASP8 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys

Caspase 8 Proteins by Grade

Find Caspase 8 Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

Caspase 8 Proteins by Origin

Find Caspase 8 Proteins for a variety of species such as anti-Human Caspase 8, anti-Mouse Caspase 8, anti-Cow Caspase 8. The species listed below are among those available. Click on a link to go to the corresponding products.

Caspase 8 Proteins by Source

Here you will find Caspase 8 Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

Caspase 8 Proteins by Protein Type

Here you can find Caspase 8 Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

Caspase 8 Proteins by Application

Find Caspase 8 Proteins validated for a specific application such as WB, SDS, ELISA, Imm. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular Caspase 8 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122169
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122170
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3132327
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3090654
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3132326
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7505388
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7392446
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7414438
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7400135
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7392440
Quantity 100 μg
Datasheet Datasheet
Reactivity Cow
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7400138
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7411414
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN4984215
Quantity 200 μg
Datasheet Datasheet
Reactivity Cow
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3008677
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Caspase 8 Proteins

Mishra, Sharma, Sharma, Singh, Sardesai, Sharma, Mishra: "Viscum articulatum Burm. f. aqueous extract exerts antiproliferative effect and induces cell cycle arrest and apoptosis in leukemia cells." in: Journal of ethnopharmacology, Vol. 219, pp. 91-102, (2018) (PubMed).

Appukuttan, Kasseckert, Micoogullari, Flacke, Kumar, Woste, Abdallah, Pott, Reusch, Ladilov: "Type 10 adenylyl cyclase mediates mitochondrial Bax translocation and apoptosis of adult rat cardiomyocytes under simulated ischaemia/reperfusion." in: Cardiovascular research, Vol. 93, Issue 2, pp. 340-9, (2012) (PubMed).

Murakami, Tolstykh, Bao, Niu, Steuer, Bao, Chang, Espiritu, Bansal, Lam, Otto, Sofia, Furman: "Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977." in: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 34337-47, (2010) (PubMed).

Chen, Xia, Fang, Hawke, Lu: "Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis." in: Molecular and cellular biology, Vol. 29, Issue 13, pp. 3657-64, (2009) (PubMed).

Sone, Nakagawa, Nakagawa, Takizawa, Matsumoto, Nagasaka, Tsuruga, Hiraike, Hiraike-Wada, Miyamoto, Oda, Yasugi, Kugu, Yano, Taketani: "hScrib, a human homologue of Drosophila neoplastic tumor suppressor, is a novel death substrate targeted by caspase during the process of apoptosis." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 13, Issue 7, pp. 771-85, (2008) (PubMed).

Hasegawa, Yamada, Komiyama, Hayashi, Ishibashi, Sunazuka, Izuhara, Sugahara, Tsuruda, Masuda, Takasu, Tsukasaki, Tomonaga, Kamihira et al.: "A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) ..." in: Blood, Vol. 110, Issue 5, pp. 1664-74, (2007) (PubMed).

Zelphati, Wang, Kitada, Reed, Felgner, Corbeil: "Intracellular delivery of proteins with a new lipid-mediated delivery system." in: The Journal of biological chemistry, Vol. 276, Issue 37, pp. 35103-10, (2001) (PubMed).

Stennicke, Salvesen: "Biochemical characteristics of caspases-3, -6, -7, and -8." in: The Journal of biological chemistry, Vol. 272, Issue 41, pp. 25719-23, (1997) (PubMed).

Patel, Gores, Kaufmann: "The role of proteases during apoptosis." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 10, Issue 5, pp. 587-97, (1996) (PubMed).

Nicholson, Ali, Thornberry, Vaillancourt, Ding, Gallant, Gareau, Griffin, Labelle, Lazebnik: "Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis." in: Nature, Vol. 376, Issue 6535, pp. 37-43, (1995) (PubMed).

Aliases for Caspase 8 Proteins

caspase 8 L homeolog (casp8.L) Proteins
death related ced-3/Nedd2-like protein (LOC661095) Proteins
caspase 8 (CASP8) Proteins
caspase-8 (LOC5563818) Proteins
caspase-8 (casp8) Proteins
caspase-8-like (LOC100222284) Proteins
caspase 8 (Casp8) Proteins
caspase 8, apoptosis-related cysteine peptidase (casp8) Proteins
ALPS2B Proteins
CAP4 Proteins
CASP-8 Proteins
Casp-8 Proteins
casp8 Proteins
CASP8 Proteins
casp8-A Proteins
caspase-8 Proteins
FLICE Proteins
MACH Proteins
Mch5 Proteins
MCH5 Proteins
xCaspase-8 Proteins
zgc:92075 Proteins
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