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|Antigen||Lamin B1 (LMNB1) Antibodies|
|Epitope||AA 266-583 Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This Lamin B1 antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|15 references available|
|Supplier||Log in to see|
Product Details anti-Lamin B1 AntibodyTarget Details Lamin B1 Application Details Handling References for anti-Lamin B1 antibody (ABIN3042505) Images
|Purpose||Rabbit IgG polyclonal antibody for Lamin-B1(LMNB1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.|
|Cross-Reactivity (Details)||No cross reactivity with other proteins.|
Rabbit IgG polyclonal antibody for Lamin-B1(LMNB1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: lamin B1
Protein Name: Lamin-B1
|Purification||Immunogen affinity purified.|
|Immunogen||E.coli-derived human Lamin B1 recombinant protein (Position: Q266-C583). Human Lamin B1 shares 95.9% and 95% amino acid (aa) sequence identity with mouse and rat Lamin B1, respectively.|
|Plasmids, Primers & others|
Target Details Lamin B1Product Details anti-Lamin B1 Antibody Application Details Handling References for anti-Lamin B1 antibody (ABIN3042505) Images back to top
|Alternative Name||LMNB1 (LMNB1 Antibody Abstract)|
Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1.
Synonyms: ADLD antibody|lamin B1 antibody|Lamin-B1 antibody|LMN antibody|LMN2 antibody|LMNB antibody| Lmnb1 antibody|LMNB1_HUMAN antibody| MGC111419 antibody|OTTHUMP00000159218 antibody
|Pathways||Apoptosis, Caspase Cascade in Apoptosis|
Application DetailsProduct Details anti-Lamin B1 Antibody Target Details Lamin B1 Handling References for anti-Lamin B1 antibody (ABIN3042505) Images back to top
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
|Restrictions||For Research Use only|
HandlingProduct Details anti-Lamin B1 Antibody Target Details Lamin B1 Application Details References for anti-Lamin B1 antibody (ABIN3042505) Images back to top
|Reconstitution||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|Buffer||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
References for anti-Lamin B1 antibody (ABIN3042505)Product Details anti-Lamin B1 Antibody Target Details Lamin B1 Application Details Handling Images back to top
|Product cited in:||
Chen, Luo, Lin, Kuang, Song: "Simulated microgravity inhibits osteogenic differentiation of mesenchymal stem cells via depolymerizing F-actin to impede TAZ nuclear translocation." in: Scientific reports, Vol. 6, pp. 30322, 2018
Timoshevskiy, Herdy, Keinath, Smith: "Cellular and Molecular Features of Developmentally Programmed Genome Rearrangement in a Vertebrate (Sea Lamprey: Petromyzon marinus)." in: PLoS genetics, Vol. 12, Issue 6, pp. e1006103, 2017
Shen, Sun, Xia, Meng, Lei, Zhao, Tang, Xue, Chen: "Overexpression of DJ-1 reduces oxidative stress and attenuates hypoxia/reoxygenation injury in NRK-52E cells exposed to high glucose." in: International journal of molecular medicine, Vol. 38, Issue 3, pp. 729-36, 2017
Chen, Jiang, Gu, Lai, Liu, Zhang: "Protection of Nrf2 against arsenite-induced oxidative damage is regulated by the cyclic guanosine monophosphate-protein kinase G signaling pathway." in: Environmental toxicology, Vol. 32, Issue 8, pp. 2004-2020, 2017
Zhang, Zhang, Zhang, Jiao, Zhang, Wang, Gong: "Glutamine ameliorates lipopolysaccharide-induced cardiac dysfunction by regulating the toll-like receptor 4/mitogen-activated protein kinase/nuclear factor-kB signaling pathway." in: Experimental and therapeutic medicine, Vol. 14, Issue 6, pp. 5825-5832, 2017
Tang, Wang, Chen, Xu, Ye: "Clinicopathologic and prognostic significance of p21 (Cip1/Waf1) expression in bladder cancer." in: International journal of clinical and experimental pathology, Vol. 8, Issue 5, pp. 4999-5007, 2016
Chen, Lai, Yang, Ruan, Chaugai, Ning, Chen, Wang: "Trimetazidine prevents macrophage-mediated septic myocardial dysfunction via activation of the histone deacetylase sirtuin 1." in: British journal of pharmacology, Vol. 173, Issue 3, pp. 545-61, 2016
Bai, Zhang, Shen, Sun, Xia, Zhang, Liu, Wang, Yuan: "Hyperglycemia and hyperlipidemia blunts the Insulin-Inpp5f negative feedback loop in the diabetic heart." in: Scientific reports, Vol. 6, pp. 22068, 2016
Wu, Liu, Duan, Gao, Li, Wang, Song, Shao, Yang, Yang: "The Involvement of Protease Nexin-1 (PN1) in the Pathogenesis of Intervertebral Disc (IVD) Degeneration." in: Scientific reports, Vol. 6, pp. 30563, 2016
Shen, Wang, Wang, Wang, Yang, Shen, Wang, Guo, Liu, Xia, Jia, Wang: "Activation of volume-sensitive outwardly rectifying chloride channel by ROS contributes to ER stress and cardiac contractile dysfunction: involvement of CHOP through Wnt." in: Cell death & disease, Vol. 5, pp. e1528, 2015
Zhu, Liu, Li, Liu, Wang, Sun, Xiong, Jiang, Zheng, Hu: "Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility." in: Carcinogenesis, Vol. 35, Issue 8, pp. 1901-10, 2014
Liu, Ma, Wu, Li, Zhang, Han, Wang, Reindl, Wu, Ma: "Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-?B signaling." in: BMC cancer, Vol. 14, pp. 686, 2014
Gao, Wu, Liu, Li, Song, Teng, Sheng, Liu, Yao, Chen, Jiang, Chen, Huang: "Interaction of NS2 with AIMP2 facilitates the switch from ubiquitination to SUMOylation of M1 in influenza A virus-infected cells." in: Journal of virology, Vol. 89, Issue 1, pp. 300-11, 2014
Yu, Chen, Wang, Kuang, Liu, Zhang, Du: "Neuroprotective effect of kaempferol glycosides against brain injury and neuroinflammation by inhibiting the activation of NF-?B and STAT3 in transient focal stroke." in: PLoS ONE, Vol. 8, Issue 2, pp. e55839, 2013
Zhang, Zhou, Wu, Zhang, Chen, Zha, Niu, Lu, Hao, Sun, Sun, Peng, Wang: "Cellular pharmacokinetic mechanisms of adriamycin resistance and its modulation by 20(S)-ginsenoside Rh2 in MCF-7/Adr cells." in: British journal of pharmacology, Vol. 165, Issue 1, pp. 120-34, 2012
ImagesProduct Details anti-Lamin B1 Antibody Target Details Lamin B1 Application Details Handling References for anti-Lamin B1 antibody (ABIN3042505) back to top