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anti-Human HCN1 Antibodies:
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Mammalian Monoclonal HCN1 Primary Antibody for ISt, IHC - ABIN1304695
Weltzien, Percival, Martin, Grünert: Analysis of bipolar and amacrine populations in marmoset retina. in The Journal of comparative neurology 2014
Show all 23 Pubmed References
Polymorphism of HCN1 is associated with breast cancer.
Study presents cryo-electron microscopy structures of the human HCN1 channel in the absence and presence of cAMP at 3.5 A resolution. HCN channels contain a K(+) channel (show KCNC4 Antibodies) selectivity filter-forming sequence from which the amino acids create a unique structure that explains Na(+) and K(+) permeability.
A new mode of regulating HCN1 trafficking: through the use of a di-arginine ER retention signal that monitors processing of the channel in the early secretory pathway.
de novo HCN1 point mutations cause a recognizable early-onset epileptic encephalopathy in humans
acute abrogation of HCN1-FLNa (show FLNA Antibodies) interaction in neurons, with the use of decoy peptides that mimic the FLNa (show FLNA Antibodies)-binding domain of HCN1, abolishes the punctate distribution of HCN1 channels in neuronal cell bodies
Studies suggest that HCN1 channels may be therapeutic targets for treatment of depressive disorders.
Wild-type presynaptic HCN1 channel function is persistently decreased following seizures.
HCN1 channels make an important contribution to the maintenance of spontaneous burst activity in embryonic cortical neuron cultures.
Hyperpolarization-activated currents are smaller and slower, input resistances are higher, and membrane time constants are longer in HCN1-deficient than in HCN1-expressing neurons of the ventral cochlear nucleus.
Genetic analysis in 48 Sudden unexpected death in epilepsy cases identified six novel and three previously reported nonsynonymous (amino acid changing) variants in HCN1 , HCN2 (show HCN2 Antibodies), HCN3 (show HCN3 Antibodies) and HCN4 (show HCN4 Antibodies).
Study shows that hyperpolarization-activated cyclic nucleotide-gated channels reduce the rate of exocytosis from a subset of cortical synaptic terminals.
in Hcn1 (-/-) mice, baseline acoustic startle response (ASR)levels were lower, temporal integration was delayed, time constants for ASR depression by noise offset were higher, and their sensitivity to brief gaps and spatial acuity was diminished
Low-voltage-activated K(+) (gKL) and hyperpolarization-activated mixed cation conductances (gh) mediate currents, IKL and Ih, through channels of the Kv1 (KCNA) and HCN families respectively and give auditory neurons the temporal precision required for signaling information about the onset, fine structure, and time of arrival of sounds.
results implicate presynaptic NMDA receptor inhibition followed by reduced activity of presynaptic HCN1 channels, which would result in an increase in glutamate (show GRIN1 Antibodies) release and postsynaptic glutamate (show GRIN1 Antibodies) receptor activity, as a mechanism of ketamine action.
HCN channels play a critical role in the separation of overlapping movement responses and allow for successful reaching behaviours. These data provide a novel mechanism for the encoding of multiple movement responses within shared networks of motor cortex. This mechanism supports a viewpoint of primary motor cortex as a site of dynamic integration for behavioural output
The study thus identifies novel candidate QTGs HCN1 that may contribute to variation in emotional learning in mice.
Data show that prostaglandin E2 receptor EP3 subtype (EP3 (show PTGER3 Antibodies)) was expressed in the interstitial cells of Cajal (ICCs) of the bladder and activated hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.
Data show that KCNJ15 inward rectifier potassium channel and hyperpolarization-activated cyclic nucleotide-gated (HCN) channel currents are changed in Trisomic neuron.
We investigated the effects of an additional genetic deletion of HCN1 on the function and survival of photoreceptors in a mouse model of CNGB1 (show CNGB1 Antibodies)-linked retinitis pigmentosa (RP).
in the absence of HCN1-mediated feedback, the amplitude of rod signals remains at high levels for a prolonged period of time, leading to saturation of the retinal pathways.
The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes.
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
, brain cyclic nucleotide gated channel 1
, brain cyclic nucleotide-gated channel 1
, potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
, hyperpolarization-activated cyclic nucleotide-gated channel 1
, hyperpolarization-activated cation channel 2