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|Antigen||Plasminogen Activator Inhibitor 2 (SERPINB2) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This SERPINB2 antibody is conjugated to Alexa Fluor 594 Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
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Product Details anti-SERPINB2 AntibodyTarget Details SERPINB2 Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human PAI-2|
Target Details SERPINB2Product Details anti-SERPINB2 Antibody Application Details Handling Images back to top
|Alternative Name||PAI-2/ SerpinB2 (SERPINB2 Antibody Abstract)|
SerpinB2 is a serine proteinase inhibitor of the ovalbumin like B clade of serpins. It was first discovered in the placenta, and given the name PAI-2 because of the ability to inhibit urokinase plasminogen activator (u-PA) at low micromolar efficiency. SerpinB2 also inhibits tissue plasminogen activator (t-PA), but with micromolar efficiency, and PAI-1 is much more efficient that SerpinB2 on both forms of plasminogen activator. The structure of PAI-2 is not terribly similar to PAI-1, however, which is an E clade serpin. SerpinB2 is made by many cell types, and is found intracellularly as an unglycosylated kDa protein, and secreted as a 60 kDa protein. SerpinB2 is found in saliva, secreted by gingival fibroblasts, and in the skin. SerpinB2 levels are elevated in serum during pregnancy, and in leukemia, breast cancer and ovarian cancer, although it was lowered in some cancers.A shorter SerpinB2 isoform of 382 amino acids, has been reported, with a predicted mass of 43.1 kDa and a pI of 5.69. The shorter form has a deletion just after the start of the mature protein, but it is unclear what the relative production and distribution is for the shorter sequence.
Synonyms: Serpin B2, Serpinb2, SerpinB2, plasminogen activator inhibitor 2, HsT1201, Monocyte Arg serpin, Monocyte Arg-serpin, PAI2A, PAI, PAI-2, PAI 2, PAI2, Placental plasminogen activator inhibitor, PAI2_RAT, PLANH2, Plasminogen activator inhibitor 2, Plasminogen activator inhibitor 2 type A, Serpin peptidase inhibitor clade B ovalbumin member 2, Urokinase inhibitor.
Application DetailsProduct Details anti-SERPINB2 Antibody Target Details SERPINB2 Handling Images back to top
|Application Notes||IF(IHC-P) 1:50-200|
|Restrictions||For Research Use only|
HandlingProduct Details anti-SERPINB2 Antibody Target Details SERPINB2 Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store at 4°C|
|Expiry Date||12 months|