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this study shows that Galphai3-deficient neutrophils display reduced transmigration but normal arrest
GIV and its substrate Galphai3 are recruited to active integrin complexes
Data show that disrupting resistance to inhibitors of cholinesterase 8A (Ric-8A (show RIC8A Proteins)) expression in hematopoietic cells results in a loss of GTP-binding protein (show DRG1 Proteins) alpha subunits Galphai2 (show GNAI2 Proteins), Galphai3, and Galphaq (show GNAQ Proteins).
Data show that guanine nucleotide-binding protein G(i) subunit alpha-1 and alpha-3 (Galphai1/3) can interact with CD14 antigen/Grb2-associated binding protein Gab1, which modulates macrophage polarization in vitro and in vivo.
Myocardial ischemia promptly regulated cardiac mRNA and with a slight delay protein levels of both Galphai2 (show GNAI2 Proteins) and Galphai3, indicating important roles for both Galphai isoforms.
The absence of Galphai2 (show GNAI2 Proteins) and Galphai3 in B cells profoundly disturbs the architecture of lymphoid organs with loss of B cell compartments in the spleen, thymus, lymph nodes, and gastrointestinal tract.
RGS19 (show RGS19 Proteins) and its partner Galpha (show SUCLG1 Proteins)-inhibiting activity polypeptide 3 (GNAI3) are involved in zVAD-, but not TNF (show TNF Proteins)-, induced cell death.
support for the hitherto untested model that Par3 (show F2RL2 Proteins)-mInsc and Galphai3 act cooperatively to polarize LGN (show GPSM2 Proteins) and promote perpendicular divisions
level of basal autophagy, autophagic induction, autophagic flux, autophagic degradation and the anti-autophagic action in macrophages that lacked Galphai3, AGS3 (show GPSM1 Proteins), or RGS19 (show RGS19 Proteins); or had been treated with pertussis toxin, were similar to controls
A constitutively active Galphai3 protein corrects the abnormal retinal pigment epithelium phenotype of Oa1 (show GPR143 Proteins)-/- mice.
Results show that Galphai3 nuclear translocation causes irradiation resistance in human glioma cells through its complexation with DNA-PKcs (show PRKDC Proteins) leading to DNA repair.
GNAI3 is identified a second gene possibly responsible for X-linked ocular albinism.
These data indicate that, unlike in taste cells, TAS2Rs couple to the prevalent G proteins, Galphai1, Galphai2 (show GNAI2 Proteins), and Galphai3, with no evidence for functional coupling to Galphagust.
Data show that auriculo-condylar syndrome (ACS (show PLA2G15 Proteins))-associated mutations in G protein subunit alpha i3 (GNAI3) produce dominant-negative Galpha (show SUCLG1 Proteins)(i3) mutant proteins that couple to endothelin type A receptor (ET(A (show EDNRA Proteins))R).
In postmortem human prefrontal cortex, adenosine A1 receptor (show ADORA1 Proteins) is coupled preferentially, if not exclusively, to Galphai-3.
transcriptional upregulation of Girdin expression and Girdin-Galphai3 signaling play crucial roles in regulating epithelial apicobasal polarity through the PAR (show JTB Proteins) complex.
We demonstrate that the GNAI3 variant is the likely cause of auriculocondylar syndrome in the original ACS1 family.
Both SH2 and GEF (show SLC2A4RG Proteins) domains of GIV are required for the formation of a ligand-activated ternary complex between GIV, Galphai3, and EGFR (show EGFR Proteins).
Low GNAI3 expression is associated with hepatocellular carcinoma.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway.
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
, guanine nucleotide-binding protein G(k) subunit alpha-like
, g(i) alpha-3
, guanine nucleotide binding protein, alpha inhibiting 3
, guanine nucleotide-binding protein G(k) subunit alpha
, Gi3 protein alpha-subunit
, guanine nucleotide binding protein alpha inhibiting 3
, G protein alpha subunit
, Guanine nucleotide binding, protein, alpha inhibiting polypeptide 3
, guanine nucleotide binding protein (G protein), alpha inhibiting 3
, alpha-subunit of G-protein, type G-alpha-i-3