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anti-Human MC2R Antibodies:
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Human Polyclonal MC2R Primary Antibody for FACS, IHC (p) - ABIN651731
Roy, Perron, Gallo-Payet: Role of asparagine-linked glycosylation in cell surface expression and function of the human adrenocorticotropin receptor (melanocortin 2 receptor) in 293/FRT cells. in Endocrinology 2010
Show all 2 Pubmed References
Human Polyclonal MC2R Primary Antibody for ELISA, WB - ABIN408678
Kilianova, Basora, Kilian, Payet, Gallo-Payet: Human melanocortin receptor 2 expression and functionality: effects of protein kinase A and protein kinase C on desensitization and internalization. in Endocrinology 2006
Results show regulation of melanocortin receptors MC2R, MC3R (show MC3R Antibodies) and MC4R (show MC4R Antibodies) gene expressions in CD8 (show CD8A Antibodies)(+) cytotoxic T-lymphocytes and CD19 (show CD19 Antibodies)(+) B lymphocytes in rheumatoid arthritis (RA) treated with tumor necrosis factor-alpha (TNF-alpha (show TNF Antibodies)) inhibitor (show ZFP36 Antibodies) adalimumab.
Four rare missense variants were identified (ACTBL2 (show ACTBL2 Antibodies) rs73757391 (5q11.2), BTD (show BTD Antibodies) rs200337373 (3p25.1), KRT13 (show KRT13 Antibodies) rs150321809 (17q21.2) and MC2R rs104894658 (18p11.21)), but only MC2R rs104894668 had a large effect size (OR = 9.66).
melanocortin receptors MC2R, MC3R (show MC3R Antibodies) and MC5R (show MC5R Antibodies) are most abundantly expressed in glandular epithelium of the endometrium
MC2R and MC1R (show MSHR Antibodies) signals are consecutively required for the regulation of EPO (show EPO Antibodies) signal transduction in erythroblast differentiation, and MC5R (show MC5R Antibodies) signal transduction is required to induce enucleation.
the MC2R gene may contribute to the development of intracerebral hemorrhage.
The A allele at rs1941088 in the MC2R gene, which encodes the adrenocorticotropic hormone (corticotropin, ACTH) receptor, is associated with a low cortisol response in critically ill children.
results suggest that Phe(7) in ACTH (show POMC Antibodies) plays an important role in ligand selectivity and that the third transmembrane domain of MC2R is crucial for ACTH (show POMC Antibodies) selectivity and potency
MC2R overexpression is associated with myelolipomas.
The patient with familial glucocorticoid deficiency was found to be homozygous for a novel mutation in the melanocortin-2 receptor gene (635insC, I154H).
Our observations suggest that MC2R is involved in prostate carcinogenesis and that targeting MC2R signaling may provide a novel avenue in prostate carcinoma treatment.
JDP2 (show JDP2 Antibodies) acts as a novel transcriptional activator of the mouse Mc2r gene, suggesting that JDP2 (show JDP2 Antibodies) may have physiological functions as a novel player in MC2R-mediated steroidogenesis as well as cell signaling in adrenal glands.
Data show that neuromedin B (NMB) expression was higher in the melanocortin 2 receptor MC2R(-/-) than in the wild-type (WT) mice.
MC2R plays an important role for regular lipolytic function and lipid composition in 3T3-L1 adipocytes.
melanocortin 2 receptor and melanocortin 5 receptor (show MC5R Antibodies) are lipolytic mediators in differentiated 3T3-L1 adipocytes
MC2R+/- pups delivered from MC2R-/- females crossed with MC2R+/+ males mice thrived poorly with MC2R-/- mothers but grew to adulthood when transferred to foster mothers after birth, suggesting that MC2R-/- females are poor mothers or cannot nurse.
The promoter activity of Mc2r is activated by FOXL2 (show FOXL2 Antibodies) in a dose-dependent manner; transcriptional activity of Mc2r is up-regulated by synergistic interaction of FOXL2 (show FOXL2 Antibodies) and NR5A1 (show NR5A1 Antibodies).
Data show that melanocortins regulate Il6 (show IL6 Antibodies) gene expression and production in 3T3-L1 adipocytes through melanocortin receptors 2 and 5.
MC2R in Y1 cells internalizes by a G protein coupled receptor (show GPR34 Antibodies) kinase dependent clathrin-coated pit (show IRF6 Antibodies) mechanism.
Data show that adrenocorticotrophic hormone resistance in tumor cell mutants is associated with a base change polymorphism in the steroidogenic factor 1 (show NR5A1 Antibodies) gene.
Novel 135-bp exon 1f of ACTH-R gene was located 1.4 kb downstream in genome of exon 1a transcribed in adrenal gland. Promoter region flanking to exon 1f may be essential for adipose tissue; that flanking to exon 1a is specific for the adrenal gland.
zfMC2R is not functional in the absence of MRAP (show MRAP Antibodies) expression.
Considering that mRNA for MC2R and the MC1R (show MSHR Antibodies) variants are present in head kidney cells, the authors hypothesized that MC2R activity is modulated in part by different binding affinities of the MC1R (show MSHR Antibodies) variants for MRAP (show MRAP Antibodies).
Data suggest enzymes in steroidogenic pathway are induced in interrenal cells during acute/chronic stress: MC2R (melanocortin 2 receptor); StAR (steroidogenic acute regulatory protein (show STAR Antibodies)); 3beta-hydroxysteroid dehydrogenase; steroid 11beta hydroxylase.
Rainbow trout melanocortin-2 receptor structure and function analysis.
ACTH (show POMC Antibodies) regulation of MC2R is highly conserved in vertebrates.
MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency.
, MC2 receptor
, adrenocorticotropic hormone receptor
, adrenocorticotropin receptor
, corticotropin receptor
, melanocortin receptor 2
, melanocortin 2 receptor
, melanocortin 2-receptor
, adrenal ACTH receptor
, G-protein-coupled receptor
, melanocortin 2 receptor-like
, putative melanocortin 2 receptor
, Adrenocorticotropin receptor
, Melanocortin receptor 2
, melanocortin 2 receptor (adrenocorticotropic hormone receptor)