|Antigen||COP9 Constitutive Photomorphogenic Homolog Subunit 8 (Arabidopsis) (COPS8) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This COPS8 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
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Product Details anti-COPS8 AntibodyTarget Details COPS8 Application Details Handling Images
|Specificity||This antibody reacts to CSN8.|
|Purification||Affinity chromatography purified via peptide column|
|Immunogen||CSN8 antibody was raised against a 15 amino acid peptide near the carboxy terminus of the human CSN8.|
|Plasmids, Primers & others|
Target Details COPS8Product Details anti-COPS8 Antibody Application Details Handling Images back to top
|Alternative Name||COPS8 (COPS8 Antibody Abstract)|
|Background||The COP9 signalosome (CSN) is an evolutionarily conserved protein complex of the eight subunits that interacts with deubiquitinating enzymes and protein kinases and is highly homologous to the lid sub-complex of 26S proteasome. The CSN complex is an essential regulator of the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-comlpexes such as SCF, CSA or DDB2. It is also involved in phosphorylation of p53, c-jun/JUN, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN8 encodes the smallest and the least conserved but first identified subunit of CSN. Recent studies show CSN8 is essential for Drosophila development and is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.Synonyms: COP9 signalosome complex subunit 8, CSN8, JAB1-containing signalosome subunit 8, SGN8, Signalosome subunit 8|
|Pathways||Cell Division Cycle|
Application DetailsProduct Details anti-COPS8 Antibody Target Details COPS8 Handling Images back to top
ELISA. Western Blot: CSN8 antibody can be used for detection of CSN8 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-COPS8 Antibody Target Details COPS8 Application Details Images back to top
|Buffer||PBS containing 0.02 % sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store the antibody undiluted at 2-8 °C.|