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HAP1 (show APEX1 Proteins) is expressed in endocrine cells of the human gut (show GUSB Proteins).
data fully support that HAP1 (show APEX1 Proteins) is a GKAP (show DLGAP1 Proteins), anchoring specifically to the cGMP-dependent protein kinase (show CDK7 Proteins) isoform Ibeta, and provide further evidence that also PKG (show PRKG1 Proteins) spatiotemporal signaling is largely controlled by anchoring proteins
HAP1 (show APEX1 Proteins) gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity
Overexpression of HAP1 (show APEX1 Proteins) reduced in vitro cell growth in breast cancer cell lines.
The results of this study found no association was found between the HAP1 (show APEX1 Proteins) T441M polymorphism and the age at onset of Huntington's disease .
The results of this study suggested that HAP1 (show APEX1 Proteins) co-localizes and associates with APP (show APP Proteins) in physiological conditions of mouse and human brain.
WT HTT regu (show HTT Proteins)lates ciliogenesis by interacting through hu (show MBD1 Proteins)ntingtin-associated protein 1 (HAP1) with pe (show PIFO Proteins)ricentriolar material 1 protein (PCM1).
HAP1 (show APEX1 Proteins)/stigmoid body interacts with the normal ataxin-3 (show ATXN3 Proteins) through Josephin (show ATXN3 Proteins) domain
sortilin (show SORT1 Proteins) stabilizes the proBDNF.HAP1 complex
ADORA2A (show ADORA2A Proteins), but not HAP1 (show APEX1 Proteins) or OGG1 (show OGG1 Proteins), may have a role in age at onset in Huntington's disease
Depleting Huntingtin-associated protein 1 (Hap1) promoted the dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A (show DYRK1A Proteins))-DDB1 and CUL4 associated factor 7 (Dcaf7 (show DCAF7 Proteins)) interaction and increased the DYRK1A (show DYRK1A Proteins) protein level.
This study also validated the interaction between HAP1 and Sec23A (show SEC23A Proteins) using co-immunoprecipitation experiments with endogenous proteins. This manuscript also reports on the high confidence interacting partners of HAP1 identified by the non-biased approach used in this study, which interestingly, consists of predominantly trafficking-related proteins
HAP1 co-localizes with synapsin I (show SYN1 Proteins) in cortical neurons as discrete puncta
findings suggest that Hap1 is important for insulin (show INS Proteins) secretion of pancreatic beta-cells via regulating the intracellular trafficking and plasma membrane localization of Cav1.2 (show CACNA1C Proteins), providing new insight into the mechanisms that regulate insulin (show INS Proteins) release from pancreatic beta-cells.
Early loss of Hap1 significantly reduces postnatal hippocampal neurogenesis, and leads to adult depressive-like behavior.
Hap1 interacts with Bcr (show BCR Proteins) on microtubules to regulate neuronal differentiation.
HAP1 regulates exocytosis by influencing the morphological docking of vesicles at the plasma membrane, the ability of vesicles to be released rapidly upon stimulation, and the early stages of fusion pore formation.
these studies identify htt (show HTT Proteins) and HAP1 as regulators of autophagosome transport in neurons
In the absence of HAP1, postnatal hypothalamic neurons exhibited reduced receptor tropomyosin-related kinase B (TRKB (show NTRK2 Proteins)) levels.
Hap1-Tsc1 (show TSC1 Proteins) interaction regulates neuronal mTORC1 signaling and neuronal morphogenesis.
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
, huntingtin-associated protein 2
, neuroan 1
, huntingtin-associated protein 1 (neuroan 1)